geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Activation of gastric afferent fibers increases coronary arterial resistance in anesthetized dogs


, : Activation of gastric afferent fibers increases coronary arterial resistance in anesthetized dogs. Journal of the Autonomic Nervous System 23(1): 25-34

Stimulation of chemically sensitive receptors in the stomach with capsaicin is known to reflexly increase heart rate, arterial pressure, left ventricular contractility, and systemic vascular resistance. What is not known, however, as if activating these gastric afferents can also evoke reflex changed in coronary arterial resistance. Therefore, in 24 chloralose-anesthetized dogs, we used a Gregg cannula and a constant flow preparation to assess left circumflex coronary arterial (LCCA) resistance while stimulating chemically sensitive gastric receptors with capsaicin. Capsaicin (60 .mu.g), applied topically to the serosal surface of the stomach, produced significant (P < 0.05) increases in heart rate (8 .+-. 2 bpm), mean arterial pressure (22 .+-. 1 mm Hg), LCCA pressure (7 .+-. 1 mm Hg), and LCCA resistance (0.04 mm Hg/m/min). These responses were still present after bilateral thoracic vagotomy, but were eliminated by bilateral thoracic splanchnicotomy. .alpha.-Adrenergic blockade eliminated and .beta.-adrenergic blockade enhanced the increases in LCCA pressure and resistance that were evoked by capsaicin. Thus, stimulating chemically sensitive receptors in the stomach can reflexly increase coronary artery resistance by .alpha.-adrenergic vasoconstriction. The possibility exists, therefore, that physiological or pathological events which activate gastric afferents can affect reflexly the coronary circulation.

US$19.90

PMID: 2902117

DOI: 10.1016/0165-1838(88)90163-4


Other references

Gooseff Michael N.; McKnight Diane M.; Runkel Robert L.; Vaughn Bruce H., 2003: Determining long time-scale hyporheic zone flow paths in Antarctic streams. In the McMurdo Dry Valleys of Antarctica, glaciers are the source of meltwater during the austral summer, and the streams and adjacent hyporheic zones constitute the entire physical watershed; there are no hillslope processes in these systems. Hyp...

Chung, T.C.; Sun, C.N., 1981: Esterases and malathion resistance in brown planthopper. The effect of the esterase inhibitor DEF (S,S,S-tributyl phosphorotrithioate) on the toxicity of malathion, parathion-methyl and parathion to 4th- and 5th-instar nymphs of a malathion-resistant strain of the brown planthopper [Nilaparvata lugens (...

Ash, J., 1983: Note on paper 'Growth rings and rainfall correlations in a mangrove tree of the genus Diospyros (Ebenaceae)', by N.C. Duke et al. The limitations of the techniques used by Duke et al. are discussed, and an alternative interpretation of the data presented using climatic growth indices.

Quivy, D., 1954: Cocaine potentiation of the hypertensive effects of adrenaline. Journal de Physiologie 46(4): 861-866

Castellaro G.G.; Rodriguez S.D.; Saez T.L., 1994: A simulation model of sheep production systems for Chile's austral zone. A sheep production simulation model was developed for the southern zone of Chile to evaluate sheep behaviour under different management systems. Estimates made by the model were compared to actual production data. The model predicted body weight,...

Ahn, S.; Kim, S., 1987: A theoretical review on strategies of agricultural technology transfer for rual development in developing countries. Seoul Taehakkyo nonghak yonku = College of Agriculture bulletin Seoul National University 12(1): 125-137

Skinner, L.M.; Jackson, M.P., 1995: Acceptor site binding of Shiga toxin, a ribosome-inactivating protein. Abstracts of the General Meeting of the American Society for Microbiology 95(0): 203

K.R.T.orp; G.W.ng; A.L.W.st; M.S.M.ran; K.F.B.onson; J.W.W.ite; J.M.n, 2012: Estimating crop biophysical properties from remote sensing data by inverting linked radiative transfer and ecophysiological models. Remote sensing technology can rapidly provide spatial information on crop growth status, which ideally could be used to invert radiative transfer models or ecophysiological models for estimating a variety of crop biophysical properties. However, t...

Haji-Karim, M.; Carlsson, J., 1978: Proliferation and viability in cellular spheroids of human origin. The capacity of cells to form growing tumor-like colonies in culture was tested by a new and unlaborious suspension technique. Six of nine tested cell lines formed spheroids, five of which started to grow. The growing spheroids reached a maximal s...

Osing, O., 1968: Silk from the sea. Sea Frontiers, 14: 18-21