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Aldo steronemia and plasma renin activity after administration of deoxy cortico sterone acetate


, : Aldo steronemia and plasma renin activity after administration of deoxy cortico sterone acetate. Bollettino della Societa Italiana di Cardiologia 23(2): 460-469

PRA [plasma renin activity] and aldosteronemia were studied in normal subjects after administration of small doses of DOCA [deoxycorticosterone acetate]. After DOCA treatment a statistically significant decrease in PRA occurred without significant variation of blood aldosterone levels. Decreased natriuresis occurred with increased kaliuresis but not of statistical importance, without simultaneous changes in electrolytes. An expansion of the extracellular fluid volume may be followed by a hyporeninemic and then by a hypoaldosteronemic effect. A non-aldosteronemic mineralocorticoid might aid diagnosis of hyporeninemia in certain forms of essential hypertension.

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