geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Alteration of membrane fusion as a cause of acute pancreatitis in the rat


, : Alteration of membrane fusion as a cause of acute pancreatitis in the rat. Digestive Diseases & Sciences 27(11): 993-1002

Infusion of supramaximal doses of caerulein induces acute edematous pancreatitis in the rat. Cannulation of the main pancreatic duct does not prevent the formation of the edema, but reveals an almost complete reduction of pancreatic flow. Using freeze-fracture techniques and thin-section EM, earliest structural alterations were observed at membranes of zymogen granules and the plasma membrane. Fusion of zymogen granules among each other leads to formation of large membrane-bound vacuoles within the cytoplasm. These and individual zymogen granules fuse with the basolateral plasma membrane, discharging their contents into the interstitial space. The findings indicate severe changes in the specificity of the intracellular membrane fusion process induced by supramaximal doses of a pancreatic secretagogue, which finally result in autodigestion of the pancreas.

US$19.90

PMID: 7140496

DOI: 10.1007/bf01391745


Other references

Scannapieco, M.; Jackson, S., 1996: Kinship care: the African American response to family preservation. The number of children entering the foster care system is increasing at an alarming rate. The increase in children entering foster care, compounded by political, economic, and social factors, has created a phenomenon in the African American commun...

Anonymous, 1989: A cost-effective non-polluting new hydrocarbon reforming process. Autothermal reforming is a process by which heat from the secondary reformer supplies the entire energy requirements of the primary steam reforming reaction. A method of attaining this is described. By this method oxygen or oxygen-enriched air is...

Smadja, D.M.; Mauge, L.; Nunes, H.; d'Audigier, Cément.; Juvin, K.; Borie, R.; Carton, Z.; Bertil, Sébastien.; Blanchard, A.; Crestani, B.; Valeyre, D.; Gaussem, P.; Israel-Biet, D., 2013: Imbalance of circulating endothelial cells and progenitors in idiopathic pulmonary fibrosis. Fibrogenesis during idiopathic pulmonary fibrosis (IPF) is strongly associated with abnormal vascular remodeling. Respective abundance of circulating endothelial cells (CEC) and endothelial progenitor cells (EPC) might reflect the balance between...

Matsushita, M.; Sawada, S.S.; Nakagata, T.; Nishi, N.; Okuda, N.; Miyachi, M., 2015: Characteristics of the number of steps in the National Health and Nutrition Survey. The mean number of steps measured in the National Health and Nutrition Survey is employed for the assessment of physical activity/exercise in "Health Japan 21," and is used to represent the amount of physical activity/exercise that citiz...

Gladyszewski; Bruynseraede, 1996: Monte Carlo simulation of nonspecular x-ray scattering profiles from multilayers. Physical Review. B, Condensed Matter 54(16): 11672-11680

Hattori, S.; Galushko, A.S.; Kamagata, Y.; Schink, B., 2005: Operation of the CO dehydrogenase/acetyl coenzyme A pathway in both acetate oxidation and acetate formation by the syntrophically acetate-oxidizing bacterium Thermacetogenium phaeum. Thermacetogenium phaeum is a homoacetogenic bacterium that can grow on various substrates, such as pyruvate, methanol, or H-2(2)/CO (It can also grow on acetate if cocultured with the hydrogen-consuming methanogenic partner Methanothermobacter the...

Muhammad Arshad; Azeem Khalid; Mahmood, M.H.; Zahir, Z.A., 2004: Potential of nitrogen and L-tryptophan enriched compost for improving growth and yield of hybrid maize. The effectiveness of recycled organic wastes/compost enriched with nitrogen and/or L-tryptophan (L-TRP) was tested for improving the growth and yield of maize by conducting pot and field experiments in Faisalabad, Pakistan. Fruit and vegetable was...

Kimpe, A.; Decostere, A.; Martel, A.; Devriese, L.A.; Haesebrouck, F., 2003: Phenotypic and genetic characterization of resistance against macrolides and lincosamides in Streptococcus gallolyticus strains isolated from pigeons and humans. The macrolide and lincosamide (ML) resistance phenotype of 65 pigeon and 30 human Streptococcus gallolyticus strains was determined by the disk diffusion method. Constitutive resistance against the tested antibiotics was seen in 13 human and 28 pi...

Scheminski, A.; Krull, R.; Hempel, D.C., 2000: Oxidative treatment of digested sewage sludge with ozone. A process to improve anaerobic biodegradation of wastewater treatment sludges is investigated. Recalcitrant organic compounds which are contained in biologically stabilized digested sludge become biodegradable by partial oxidation using ozone and...

Edwards, F.W., 1929: The African species of Dixa (Diptera, Dixinae). Entomologist London, 62: 160-161