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Alternative mechanism of protein a immunoglobulin interaction the v h associated reactivity of a monoclonal human immunoglobulin m


, : Alternative mechanism of protein a immunoglobulin interaction the v h associated reactivity of a monoclonal human immunoglobulin m. Journal of Immunology 135(2): 1232-1238

The Ig site(s) that mediates the alternative mechanism of interaction between Ig and staphylococcal protein A (SpA) was studied by using a monoclonal human IgM. Several IgM fragments were tested for their inhibitory effect in a competitive binding assay of 125I-IgM to SpA. Only those fragments containing Fab.mu. pieces showed some inhibitory activity. The reactivity of the Fab.mu. region was retained in some of its subfragments, such as Fv or the VH domain, unlike isolated L chains or VL domains. Antibodies specific for the VH domain completely inhibited the SpA-IgM interaction. These results indicate that the alternative SpA-binding site of IgM is located in VH regions.

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Anonymous, 1976: Grading and classifying industrial wood. In 1973, by general agreement of the Swiss Wood Industry, new simplified grading and classifying rules were proposed and tested over a two year period for a better understanding between all sections of the industry. Definitions, criteria and expla...

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Levins, P.L.; Rogers, W.I., 1965: Ajuvant Use Of Hn2 (Nsc-762) And Thiotepa (Nsc-6396)--Progress Report. Cancer ChemoTherapy Reports 44: 27-30

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Irfan, A.; Qureshi, A., 1995: Intracranial space occupying lesions--review of 386 cases. An analysis of 386 cases of Intracranial Space Occupying Lesions (SOL) including neoplastic and inflammatory masses diagnosed and treated at Jinnah Postgraduate Medical Centre, Karachi over a period of 2 years is presented. C.T. Scan and MRI were...

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Ushakov, G.N.; Gasilin, V.S.; Konovalov, S.V.; Melent'ev, A.S.; Kruglov, V.A.; Rostokin, I.A.; Akhromeev, A.V., 1989: Effectiveness of primary multifactorial prevention of ischemic heart disease. Sovetskoe Zdravookhranenie: 34-37