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An electro optic study of the effect of certain amino glycoside antibiotics on the electrical polarizability of sensitive dependent and resistant of escherichia coli


, : An electro optic study of the effect of certain amino glycoside antibiotics on the electrical polarizability of sensitive dependent and resistant of escherichia coli. Microbios 17(68-69): 133-140

A study was made of the effect of certain aminoglycoside antibiotics on the electrical properties of the surfaces of 1 sensitive, 2 resistant and 1 dependent form of E. coli K-12. The method employed was to observe the change in scattered light produced when the bacteria in suspension are orientated by an applied A.C. electric field. The effect of the antibiotics was analyzed in terms of drug accumulation at the bacterial surface. Differences were noted in the responses of the sensitive form to different aminoglycosides and an attempt was made to correlate these differences with minimum inhibitory concentrations. Differences were also noted in the response of certain resistant and dependent forms of E. coli to streptomycin.

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