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Analysis of protective mechanism against infection with ectromelia virus

, : Analysis of protective mechanism against infection with ectromelia virus. Boei Ika Daigakko Zasshi 8(4): 303-308

Most of the infective viruses injected into mice i.v. at a dose of 6-8 .times. 103 PFU [plaque-forming units] were trapped in the liver within 30 min. There was a transient 10-fold decrease in the titer of virus by day 1. Antiviral activity in the initial phase was inhibited by carrageenan. The protection in this early phase of infection seemed to be attributable to the function of fixed macrophages. Virus in the organs increased progressively and extensively from 1 to 3 days to reach a maximum concentration. Viral growth during this period was markedly enhanced by .gamma.-irradiation or carrageenan-treatment. Accumulation of free phagocytes seemed to suppress the viral growth in this period. The infective virus titer began to decrease from day 4 and became undetectable by day 8. When carrageenan was injected i.p. 3 days after challenge with viruses, enhancement of viral growth was observed; cytotoxic T cell response was induced in the spleen as measured in a 51Cr release assay using virus-infected target cells. The suppressive effect on viral growth in the last phase may be dependent on immunologically activated macrophages and was reversed by .gamma.-irradiation and carrageenan. The protection against ectromelia virus appears to depend mainly on macrophages, since carrageenan depletes macrophages but not cytotoxic T cells.


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