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Analysis of the rates of dietary induced changes in chick kidney arginase ec 3.5.3.1 activity


, : Analysis of the rates of dietary induced changes in chick kidney arginase ec 3.5.3.1 activity. Proceedings of the Society for Experimental Biology and Medicine 164(3): 347-350

The turnover rate of dietary induced changes in chick kidney arginase was studied. The enzyme activity in kidney was increased or decreased following addition or removal of certain dietary amino acids to the diet of chicks. Excesses of dietary arginine or lysine caused the kidney arginase to increase to a new steady-state level with a half-time of 2.6-3.8 days; when these amino acids were removed from the diet or when .alpha.aminoisolytic acid was added to the diet, the activity rapidly declined to a lower level with a shorter half-time of 0.8-1.9 days. The rate constant for degradation was changed from 0.18-0.27 to 0.36-0.90 under these conditions. These dietary amino acids might alter the rate of arginase degradation in chick kidney.

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