geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Anti hypertensive activity of 16 16 di methyloxaalkyl prostaglandins of the prostaglandin a 2 prostaglandin e 2 and trans delta 2 11 deoxy prostaglandin e 1 series structure activity relationships


, : Anti hypertensive activity of 16 16 di methyloxaalkyl prostaglandins of the prostaglandin a 2 prostaglandin e 2 and trans delta 2 11 deoxy prostaglandin e 1 series structure activity relationships. Prostaglandins 20(1): 153-170

Utilizing Corey's synthesis, a variety of prostaglandins (PG) with a modified .omega.-side chain were prepared. The 16,16-dimethyloxaalkyl PGA2 analogs had potent antihypertensive activity. HR 466 (16,16-dimethyl-18-oxa-PGA2), the best compound out of this series was active for 5-6 h after oral administration of 0.1 mg/kg to conscious renal hypertensive dogs. The corresponding PGE2 analogs were also potent antihypertensive compounds, but were much more spasmogenic. Structural variations within the trans-.DELTA.2-11-deoxy-PGE1-series, in both side chains, gave HR 601 (trans-.DELTA.2-15.alpha.-acetoxy-16,16-dimethyl-18-oxa-11-deoxy-PGE1-methylester) which was orally active in the hypertensive dog with similar activity to HR 466.

US$29.90


Other references

Dixon R., 1980: Radio immunoassay for the hypnotic flunitrazepam in plasma. Federation Proceedings: Abstract 1432

Harding, S.A.; Shah, N.; Briggs, N.; Sasse, A.; Larsen, P.D., 2013: Complex transradial percutaneous coronary intervention using a sheathless guide catheter. Radial access for percutaneous coronary intervention (PCI) has been shown to reduce access site complications, improve patient comfort and reduce mortality. Use of a sheathless guiding catheter for transradial PCI has the potential reduce trauma t...

Sapin-Jaloustre, H., 1953: Tetanus in the department of Seine from 1944 to 1952; different etiologies. Concours Medical 75(50): 4273-4276

Cookson, J.Jr, 1974: Virus and water supply. Journal 66 (12) 707-711

Anonymous, 1993: Sustainable potato farming. Several Oregon farmers discuss their experiences growing potatoes without environmentally damaging chemicals and describe their techniques for soil, weed, insect, and disease management.

Collinet J., 1969: Stone lines in the middle Ogooue basin, Gabon. Reworked ferralitic soils, classification of stone lines, residual elements from parent rock, earlier pedogenesis, and alluvium, hypothesis on the evolution of stone lines.

Hashima, Hisao, 1956: Studies on the prenatal growth of the mouse with special reference to the site of implantation of the embryo. All studies have shown embryos to be slightly more numerous in the left horn of the uterus than in the right. Where fewer they average heavier. They face up or down the uterus apparently at random. Weights increase away from the ovary. Weights of...

Sanden, W. v., 1956: Sibirische Drossel (Turdus sibiricus) am Dummer. Ornithologische Mitteilungen, 8: 52

Jaiswal, A.Kumar.; Khare, P.; Joshi, S.; Rawat, K.; Yadav, N.; Sundar, S.; Dube, A., 2015: Immunological consequences of stress-related proteins--cytosolic tryparedoxin peroxidase and chaperonin TCP20--identified in splenic amastigotes of Leishmania donovani as Th1 stimulatory, in experimental visceral leishmaniasis. In earlier studies, proteomic characterization of splenic amastigote fractions from clinical isolates of Leishmania donovani, exhibiting significant cellular responses in cured Leishmania subjects, led to the identification of cytosolic tryparedox...

Lu, X.; Tang, J.; Liu, Z.; Li, M.; Zhang, T.; Zhang, X.; Ding, K., 2016: Discovery of new chemical entities as potential leads against Mycobacterium tuberculosis. NlmCategory="UNASSIGNED">A series of biheterocyclic (1H-indole, benzofuran, pyrazolo[1,5-a]pyrimidine, pyrazolo[1,5-a]pyrimidin-5(4H)-one, imidazo[2,1-b]thiazole and pyrazolo[5,1-b]thiazole) derivatives were synthesized and evaluated...