+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Antibodies to ribosomes in chronic active hepatitis

, : Antibodies to ribosomes in chronic active hepatitis. Gastroenterology 76(1): 139-143

A recently developed Farr-type radioimmunoassay for the detection of antibodies to tritium-labeled HeLa cell cytoplasmic ribosomes was evaluated as a serologic test in a variety of liver diseases. Ribosomal antibodies were detected in the sera of 31.4% of 70 patients with chronic active hepatitis (CAH) and primary biliary cirrhosis compared with only 4.2% of patients with chronic persistent hepatitis, acute viral hepatitis, alcoholic liver disease, and miscellaneous liver diseases (X2 = 17.89, P less than 0.001). The level of ribosomal binding activity was also significantly higher in sera of patients with CAH and primary biliary cirrhosis (15.4% vs 6.5%; t = 5.61, P less than 0.001). The antibodies were observed almost exclusively in HBsAg-negative CAH with autoimmune features and infrequently at lower titer in HBsAg-positive CAH or CAH without HBsAg or autoantibodies. Inhibition experiments with purified ribosomal RNA suggested that the ribosomal antibodies are in part reactive with ribosomal RNA. Ribosomal antibodies appear to represent another example of the exaggerated immune response associated with CAH and primary biliary cirrhosis.


PMID: 758135

Other references

Marion Giles M., 2003: Natural gas hydrate stability in the Arctic. Pages 164 2003

Eom, I-Yong.; Kim, J-Young.; Lee, S-Min.; Cho, T-Su.; Yeo, H.; Choi, J-Weon., 2013: Comparison of pyrolytic products produced from inorganic-rich and demineralized rice straw (Oryza sativa L.) by fluidized bed pyrolyzer for future biorefinery approach. The objectives of this study were to investigate the effects of inorganic constituents on the fast pyrolysis of the biomass and to determine the yields as well as physicochemical properties of pyrolytic products. The pyrolytic products were obtain...

Srivastava, KP., 1988: A textbook of applied entomology methods of insect pest control Volume 1. Unknown

Wong W.W.; Leggitt J.L.; Clarke L.L.; Klein P.D., 1991: Rapid preparation of pyrogen free deuterium and oxygen 18 labeled water for human nutrition studies. We describe a compact ultrafiltration system for the removal of pyrogens and bacteria from water labeled with the stable isotopes of deuterium and oxygen-18. The ultrafiltration system is constructed from readily available commercial components an...

Avni, E.F., 1992: Ultrasound of the kidney. Pediatric Nephrology 6(5): C48

Cusnir, I.; Dobing, S.; Jones, N.; Russell, A., 2016: Antimalarial drugs alone may still have a role in rheumatoid arthritis. Antimalarials have been used for the treatment of rheumatoid arthritis (RA) for several decades. Current guidelines do not include the use of these drugs alone for RA patients. The purpose of the study is to review RA patients, to find those who h...

Bohe, M.; Cedermark, B.; Damber, L.; Lewin, F.; Lindmark, G.; Nordgren, S.; Påhlman, L.; Sjödahl, R., 2000: Quality registry for better treatment of rectal cancer established. Economical support is required to use the benefits of the information. The treatment of rectal cancer has changed significantly during the last 30 years. With improved surgical technique and the introduction of preoperative radiotherapy sphincter preserving surgery is now predominant and the rate of local recurrence...

Watkins, J.; Elby, A., 2014: Context dependence of students' views about the role of equations in understanding biology. Students’ epistemological views about biology-their ideas about what "counts" as learning and understanding biology-play a role in how they approach their courses and respond to reforms. As introductory biology courses incorporate...

Williams Bruce, 2003: Telemedicine; emerging technology for health-related research. Open-File Report - U S

Przewloka, M.R.; Venkei, Z.; Glover, D.M., 2009: Searching for Drosophila Dsn1 kinetochore protein. The Mis12/MIND kinetochore complex is composed of 4 subunits of which the Dsn1 protein is a crucial component in all organisms where it has been identified. In Caenorhabditis elegans, depletion of Dsn1 results in a so-called "kinetochore null...