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Assessment of the systemic effects primary dermal irritation and ocular irritation of chlorhexidine acetate solutions

, : Assessment of the systemic effects primary dermal irritation and ocular irritation of chlorhexidine acetate solutions. Journal of the American College of Toxicology 4(6): 309-320

The biologic effects of various chlorhexidine acetate (CIAc) solutions containing isopropyl alcohol, Synperonic NP8, and carmoisin were evaluated (1) following intraperitoneal (IP) administration in rats for 5 consecutive days followed by a 5-day recovery period, (2) by measuring the primary irritation of the skin by a patch-test technique on intact and abraded skin of rabbits, and (3) following instillation into the eyes of rabbits followed by washing 50% of the treated eyes with lukewarm water in order to evaluate ocular irritation. Physiologic saline solution served as the control article throughout the studies. There was a high incidence of deaths (i.e., 28/32 and 11/16 for CIAc solutions with and without Synperonic NP8, respectively) among rats receiving IP treatment at a dosage of 40 ml/kg per day for 5 consecutive days. No toxicologically significant treatment-related changes were observed in rats treated IP with either surfactant or isopropyl alcohol with Synperonic NP8. Toxicity of CIAc solution appears to be due to a chemically induced peritonitis with no evidence of systemic toxicity. CIAc solution or the respective surfactants elicited either no reaction or a mild dermal irritation in the rabbit. Likewise, CIAc solution with or without Synperonic NP8 and the three respective surfactants did not cause any significant ocular irritation changes that are considered of toxicologic significance. It is concluded that (1) the multiple IP administration of CIAc solution elicited a toxic response in rats, and thus, caution must be exercised when the solution is useed for the purposes of peritoneal lavage, and (2) CIAc solution is a mild dermal and ocular irritant in the rabbit.


Other references

Vaishya R.D.; Singh V.K.; Qazi M.F., 1989: Effect of herbicides on nutrient leaching from rice leaves. International Rice Research Newsletter 14(6): 14

Keyserling H.; Thompson S.; Robinowitz M.; Lee F.; Pereira L.; Coleman R.M.; Bain R.; Nahmias A., 1985: Prevalence of genital herpes and or herpes simplex virus type 2 antibodies in 2 obstetric populations. Pediatric Research 19(4 PART 2): 297A

Walkup, K.R.; Shumaker, R.W.; Pruetz, J.D., 2011: Orangutans (Pongo spp.) may prefer tools with rigid properties to flimsy tools. Preference for tools with either rigid or flexible properties was explored in orangutans (Pongo spp.) through an extension of D. J. Povinelli, J. E. Reaux, and L. A. Theall's (2000) flimsy-tool problem. Three captive orangutans were presented...

Ramesha, Y.S.; Ramanna, R.; Achoth, L., 1988: Supply response of rice in Karnataka. The paper estimates the supply response of rice to price in Karnataka, India. Previous studies have shown that there is a positive supply response to price incentives in developing countries. The magnitude varies according to the nature of the cro...

Elina, Ga, 1972: On mapping methods and calculating berry resources of the bogs of Karelia. Osnovnye Printsipy Izucheniia Bolotnykh Biogeotsenozov: 0-89

Conn, C.E.; Day, F.P., 1996: Response of root and cotton strip decay to nitrogen amendment along a barrier island dune chronosequence. The influence of nitrogen amendment on fine root decomposition was evaluated on sites located along a barrier island chronosequence (24-, 36-, and 120-year-old dunes). The degree to which exogenous nitrogen limits decay at each site was evaluated...

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Falck, I., 1958: Diffuss sclerosis; review from the viewpoint of the internist. Das Deutsche Gesundheitswesen 13(21): 637-643

Park, H.Young.; Kloxin, C.J.; Abuelyaman, A.S.; Oxman, J.D.; Bowman, C.N., 2012: Stress relaxation via addition-fragmentation chain transfer in high T(g), high conversion methacrylate-based systems. To reduce shrinkage stress which arises during the polymerization of crosslinked polymers, allyl sulfide functional groups were incorporated into methacrylate polymerizations to determine their effect on stress relaxation via addition-fragmentatio...

Kuehne John; Wilson Clark R.; Johnson Stuart, 1996: Estimates of the Chandler wobble frequency and Q. Journal of Geophysical Research, B, Solid Earth and Planets 101(6): 13,573-13,579