+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Attempt to use vincristine and colcemid to measure proliferative rates in normal human epidermis in vivo

, : Attempt to use vincristine and colcemid to measure proliferative rates in normal human epidermis in vivo. British Journal of Dermatology 104(3): 243-248

A range of doses of vincristine (0.5-10 .mu.g) or colcemid (5-100 .mu.g) injected intradermally into normal volunteers failed to yield any significant accumulation of arrested mitoses despite an apparently successful block of cells in metaphase by the highest 3 doses of each drug. Possible reasons for the failure to see accumulation are discussed. Normal human epidermis probably is not a suitable system for application of the metaphase-arrest technique using intradermal injection.


PMID: 7213557

Other references

Reid, J.M.; Forster, A.; Fitch, P.S.; Smith, F.W.; Coleman, R.J., 2008: An atypical case of neuralgic amyotrophy with respiratory muscle weakness: case report and review of literature. This report is of an atypical case of neuralgic amyotrophy with a Horner's syndrome, bilateral brachial plexus, lumbar plexus and phrenic nerve involvement. The diagnosis isconfirmed based on a classical history and examination findings with...

Kamiya, H.; Yasuda, T.; Nagamine, H.; Sakakibara, N.; Nishida, S.; Kawasuji, M.; Watanabe, G., 2001: Surgical treatment of primary cardiac tumors: 28 years' experience in Kanazawa University Hospital. To examine the clinical features of primary cardiac tumors, 34 patients who underwent surgical treatment from 1973 to 2000 at the Kanazawa University Hospital were analyzed and the literature was reviewed. The 34 patients were divided into 3 categ...

Rosenthal T.L.; Akiskal H.S.; Scott Strauss A.; Rosenthal R.H.; David M., 1981: Familial and developmental factors in characterological depressions. Patients with chronic low-grade depressions (screened to exclude primary affective illness and those secondary to rigorously defined nonaffective disorders) were divided into subaffective dysthymic vs. character-spectrum groups and compared to 40...

Shi, R.; Luo, J., 2003: Polyethylene glycol may reduce oxidative stress through direct interaction with mitochondria following spinal cord trauma. Polyethylene glycol (PEG) has been shown to reduce oxidative stress following traumatic spinal cord injury. One mechanism of action is thought to be through plasma membrane repair, since PEG is known to restore membrane integrity and is not a free...

Landis, E.M.; Jonas, L.; Angevine, M.; Erb, W., 1932: The Passage Of Fluid And Protein Through The Human Capillary Wall During Venous Congestion. Journal of Clinical Investigation 11(4): 717-734

Andresen, L.; Sala, E.; Kõiv, V.; Mäe, A., 2010: A role for the Rcs phosphorelay in regulating expression of plant cell wall degrading enzymes in Pectobacterium carotovorum subsp. carotovorum. The Rcs phosphorelay is a signal transduction system that influences the virulence phenotype of several pathogenic bacteria. In the plant pathogen Pectobacterium carotovorum subsp. carotovorum (Pcc) the response regulator of the Rcs phosphorelay,...

Clark, D.B.; Baum, A.; D.B.llis, M.; Rao, A., 1999: Platelet catecholamines and adverse life events in adolescent alcohol use disorders. Alcoholism Clinical & Experimental Research 23(5 SUPPL ): 127A, May

Shima, Akihiro, 1993: International Congress Series, No 1021 Frontiers of photobiology; 11th International Congress on Photobiology, Kyoto, Japan, September 7-12, 1992. Shima, A , Ichahashi, M , Fujiwara, Y , Takebe, H International Congress Series; Frontiers of photobiology XXVIII+568P

Battifora, H., 1991: Specificity of immunohistochemical expression of P-glycoprotein. Human Pathology 22(5): 506-507

Bolea, S.; Avignone, E.; Sanchez Andres, J.V.; Berretta, N.; Cherubini, E., 1998: Non-NMDA receptor activation is essential for generating giant depolarizing potentials in neonatal rat hippocampal slices. Journal of Physiology (Cambridge) 509P: 69P, June