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Behavioral and pharmacological studies of methamphetamine induced stereotypy of mice by the open field method


, : Behavioral and pharmacological studies of methamphetamine induced stereotypy of mice by the open field method. Yakugaku Zasshi 105(8): 775-783

The methamphetamine-induced stereotypy of mice in a three-dimensional open field divided into nine unit spaces was visually observed. Each space was a little larger in size than the mice. The resultant positional behaviors were analyzed by use of four measures, namely, total frequency of visits to unit spaces (N), spacial distribution of the animal location (HI) obtained by the equation .**GRAPHIC**. (bits), where pi was the frequency of visits to a unit space numbered as i/N, approximated visit direction (HII) obtained by the equation .**GRAPHIC**. (bits), where pij was the frequency of visits from the i unit space to a unit space numbered as j/frequency of visits to the i unit space, and visit direction from the 6th unit space (H6 .fwdarw.) obtained by the equation .**GRAPHIC**. (bits), where p6j was the frequency of visits from the 6th unit space to the j unit space/frequency of visits to the 6th unit space. Increasing N methamphetamine gave an maximum effect at 2-4 mg/kg, s.c., but dose-dependently reduced the entropies, that is, HI, HII and He .fwdarw. Haloperidol (0.1-1 mg/kg, p.o.), metoclopramide (1-10 mg/kg, p.o), chlorpromazine (3-30 mg/kg, p.o.) and sulpiride (1-100 mg/kg, i.p.) dose-dependently antagonized the methamphetamine (8 mg/kg, s.c.)-induced stereotypy. These results suggest that the present method is useful for the analysis of stereotypy and a better understanding of pharmacological activities of antipsychotic drugs.

US$29.90

PMID: 2868114


Other references

Mehboob, S.; Luo, B.H.o; Fung, L.W.M.i, 2001: Partial domains association in model peptides of alphabeta spectrin. Biophysical Journal 80(1 Part 2): 61a, January

Sharma, A.; Plessinger, M.A.; Miller, R.K.; Woods, J.R., 1993: Progesterone antagonist mifepristone (RU 486) decreases cardiotoxicity of cocaine. RU 486, a potent progesterone antagonist, was used to determine whether RU 486 blocks the enhanced cardiotoxicity of cocaine mediated by progesterone upon rat papillary muscles. Groups of nonpregnant rats were pretreated with: progesterone for 3 d...

Sorscher, S., 2016: Understanding the Significance of Mutations in Tumor Suppressor Genes Identified Using Next-Generation Sequencing: A Case Report. Next-generation sequencing (NGS) of tumors has been heralded as a promising tool to identify 'actionable' abnormalities susceptible to therapies targeting these mutated genes. Inhibiting the oncoprotein expressed from a single dominant m...

Hoetker H., 1989: Sex ratios and weights of meadow pipits anthus pratensis in their winter quarters. An analysis of wing length data of wintering Meadow Pipits has shown that the population wintering in the north of the range consists mainly of males and in the major (southern) part of the wintering range the sex ratio is more or less even. Meado...

Aires, M.; Weissheimer, A-M.; Rosset, I.; de Oliveira, F.A.; de Morais, E.P.; Paskulin, L.M.G., 2012: Transcultural adaptation of the filial responsibility interview schedule for Brazil. In developed countries, filial responsibility in relation to caring for elderly parents has been systematically studied. In Brazil and other developing countries, however, it is a relatively new topic and has not yet been included in the research...

Lan, T.; Bhagat, L.; Wang, D.; Dai, M.; Kandimalla, E.R.; Agrawal, S., 2009: Synthetic oligoribonucleotides containing arabinonucleotides act as agonists of TLR7 and 8. In continuation of our studies with stabilized immune modulatory RNA (SIMRA) compounds, we have synthesized novel SIMRA compounds incorporating arabinonucleotides to study their effects on TLR7 and TLR8 activation. The SIMRA compounds containing a...

Belotkach, Mp, 1977: Study of the process of basic soil tillage with use of disks and engines. Mekhanizatsiia i elektrifikatsiia sel'skogo khoziaistva: 0 9-13

Chirkov, V., 2005: Plant biomass thermochemical conversion modules for mini-CHP. The basic design principles of plant biomass thermochemical conversion modules were analysed with regard to the advantages that can be benefited from their application in small cogeneration of heat and power (CHP) stations. The specific features o...

Hoffman, F.L., 1934: Compulsory Sickness Insurance: Part VII. California and Western Medicine 41(4): 262-263

Wegorek, W., 1978: Professor Doctor Tadeusz Stob. Prace naukowe0(1): 5-9