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Benzodiazepine inhibition of adenosine uptake is not prevented by benzodiazepine antagonists


, : Benzodiazepine inhibition of adenosine uptake is not prevented by benzodiazepine antagonists. European Journal of Pharmacology 87(1): 121-126

Uptake of [3H]adenosine into rat cerebral cortex synaptosomes was studied. Hexobendine (10-5 M) and the benzodiazepine agonists diazepam (10-5 M) and flurazepam (10-4 M) significantly inhibited this uptake, but only if the compounds were preincubated for 10 min in the case of benzodiazepines. The benzodiazepine antagonists Rol5-1788 [ethyl-8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate] (10-5 M) and CGS 8216 [2-phenylpyrazolo [4,3c]quinolin-3(5H)-one(10-5 M)] failed to reverse the action of benzodiazepine agonists or hexobendine on [3H]adenosine uptake. Inhibition of adenosine uptake processes by benzodiazepines apparently do not contribute to their behavioral effects.

US$19.90

PMID: 6404638

DOI: 10.1016/0014-2999(83)90057-2


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