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Beta adrenergic blocking agents part 17 1 phenoxy 3 phenoxyalkylamino 2 propanols and 1 alkoxyalkylamino 3 phenoxy 2 propanols


, : Beta adrenergic blocking agents part 17 1 phenoxy 3 phenoxyalkylamino 2 propanols and 1 alkoxyalkylamino 3 phenoxy 2 propanols. Journal of Medicinal Chemistry 20(12): 1653-1656

The synthesis of a series of derivatives of 1-phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propanols is described. The compounds were investigated for their .beta.-adrenoceptor blocking properties and many showed a surprising degree of cardioselectivity when tested in vivo in anesthetized cats for their effects on an isoproterenol-induced tachycardia and depressor response. The structure-activity relationship shown by this series of compounds is related to that of known cardioselective analogues and a possible reason for their cardioselectivity is discussed.

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