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Biosynthesis and production of tetrocarcin a a new anti tumor antibiotic in chemically defined medium


, : Biosynthesis and production of tetrocarcin a a new anti tumor antibiotic in chemically defined medium. Agricultural & Biological Chemistry 46(4): 1021-1026

A chemically defined medium was devised to examine the growth [of Micromonospora chalcea], production and biochemical pathway of tetrocarcin A. The production of tetrocarcin A was greatly stimuliated by L-leucine and its corresponding keto acid, .alpha.-ketoisocaproate, suggesting that L-leucine is involved in the biosynthesis of tetrocarcin A. About 10-12 .mu.g/ml of tetrocarcin A was produced in a chemically defined medium consisting of 20 g sucrose, 2.5 g KNO3, 5 g MgSO4.cntdot.7H2O, 5 g KH2PO4 and 1 g L-leucine/l of water (pH 7.0).

US$29.90


Other references

Fontes, G.; Brito, A.C.; Calheiros, C.M.; Antunes, C.M.; da Rocha, E.M., 1994: Present status of bancroftian filariasis in Maceió, State of Alagoas, Brazil. Epidemiological and entomological surveys were carried out in the human and mosquito populations in Maceió, Alagoas, in order to assess the present status of bancroftian lymphatic filariasis. Examination of thick blood smears of 10,450 students f...

Ishikawa, Y., 1995: A zygotic recessive mutation, tb that perturbs straightness of the anterior-posterior axis at the midbrain in the Medaka embryo. Zoological Science (Tokyo) 12(SUPPL ): 91

Hammond, E.C.; Horn, D.; Hammond, E.C.; Horn, D., 1984: Landmark article March 15, 1958: Smoking and death rates--report on forty-four months of follow-up of 187,783 men. By E. Cuyler Hammond and Daniel Horn. JAMA 251(21): 2840-2853

Stuyver, Lieven, 2004: Method for detection of drug-selected mutations in the HIV protease gene. The present invention relates to a method for the rapid and reliable detection of drug-selected mutations in the HIV protease gene allowing the simultaneous charaterization of a range of codons involved in drug resistance using specific sets of pr...

Ye, Q.L.; Wagner, M.; Smythe, S.; Mac Neil, S., 1991: Thyrotrophin, but not forskolin, increases intracellular free calcium and calmodulin in pig thyroid cells. The effects of TSH and forskolin were examined on intracellular free calcium ([Ca2+]i) and calmodulin in normal pig thyroid cells in culture. TSH was found to produce acute increases in [Ca2+]i in pig cells. Responses were seen at concentrations o...

Hedau, S.; Batra, M.; Singh, U.Rani.; Bharti, A.C.; Ray, A.; Das, B.C., 2016: Expression of BRCA1 and BRCA2 proteins and their correlation with clinical staging in breast cancer. The purpose of this study was to evaluate the level of expression of the BRCA1 and BRCA2 proteins in sporadic breast cancer cases to determine the functional role of these genes in breast carcinogenesis. Paraffin embedded histologically proven inv...

Bosco, D.B.; Kenworthy, R.; Zorio, D.A.R.; Sang, Q-Xiang.Amy., 2016: Human mesenchymal stem cells are resistant to Paclitaxel by adopting a non-proliferative fibroblastic state. Human mesenchymal stem cell (hMSC) resistance to the apoptotic effects of chemotherapeutic drugs has been of major interest, as these cells can confer this resistance to tumor microenvironments. However, the effects of internalized chemotherapeuti...

Chaudhuri P.K., 1990: N iodosuccinimide as an oxidant a novel dimeric compound from a styrene derivative. A novel dimeric compound characterised as 2A has been obtained in the reaction of a styrene derivative (1) with N-iodosuccinimide (UV, IR, PMR and MS data).

Fujisawa, T.K.bori, T.O.ta, H., 1976: A simple total synthesis of cyclopentanoid C9 -terpene lactones , Menyanthes trifoliata. Journal of the Chemical Society: 6 186-187

Csillag, J.; Redly, M., 1993: Determination of the composition of different soil water fractions retained at distinct suction values. A method is described for extracting fractions of the soil solution retained at different pF values. The pH, electrical conductivity, ionic concentrations and ionic activity were determined in different fractions of the soil solution of two halomo...