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Biphasic effects of prolylleucylglycinamide and tyrosylprolylleucylglycinamide on apomorphine induced stereotypy in rats

, : Biphasic effects of prolylleucylglycinamide and tyrosylprolylleucylglycinamide on apomorphine induced stereotypy in rats. Pharmacology Biochemistry & Behavior 25(4): 757-762

The effects of several doses of MIF-1 and Tyr-MIF-1 (0.2, 0.5, 1.0 and 5.0 mg/kg, SC) on the stereotypic behavior induced by various doses (0.08, 0.2, 0.5, 1.0 and 2.0 mg/kg. SC) of apomorphine (APO) were tested in rats. MIF-1 increased the stereotypic behavior induced by 0.5 and 1.0 mg/kg of APO, but decreased the stereotypic behavior induced by 2.0 mg/kg of APO. Tyr-MIF-1 showed a biphasic effect similar to that exerted by MIF-1. The results suggest that the type of response to MIF-1 and Tyr-MIF-1 after APO is influenced by the activity of central dopaminergic neurons.


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