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Borderline hypertension: relationship between age, hemodynamics and circulating catecholamines

, : Borderline hypertension: relationship between age, hemodynamics and circulating catecholamines. Circulation 64(4): 760-764

The relationships between age, systemic and renal hemodynamics, circulating catecholamines (norepinephrine, epinephrine and dopamine) and intravascular volumes were studied in 38 normotensive subjects and in 77 patients with borderline essential hypertension. Borderline hypertensive patients had a higher cardiac index (p less than 0.02) and renal blood flow (p less than 0.05) than normotensive subjects if they were younger than 30 years of age, whereas in older patients no difference was observed. In contrast, total peripheral resistance was normal in young borderline hypertensive patients, but significantly increased (p less than 0.02) in patients older than age 40 years. Cardiac output (r = -0.28, p less than 0.01) and renal blood flow (r = -0.47, p less than 0.001) correlated inversely with age in the entire population and in both subgroups. Cardiac output also correlated closely with renal blood flow in all subjects (r = 0.45, p less than 0.001). Circulating norepinephrine levels increased with age (r = 0.25, p less than 0.05), whereas epinephrine concentration tended to decrease. Plasma and total blood volume correlated directly with cardiac output (r = 0.39, p less than 0.001) and inversely with peripheral resistance (r = -0.34, p less than 0.001). These data indicate that the hyperdynamic circulation (high cardiac output and renal blood flow) of borderline hypertension is found predominantly in patients younger than age 30 years. Older patients are characterized by an elevated total peripheral resistance and normal cardiac output. The age-dependent increase in circulating norepinephrine and decrease in epinephrine levels may participate in the shift of the hemodynamic profile from high-cardiac-output hypertension in the young to a high-arteriolar-resistance hypertension in the older patient.


PMID: 7273377

DOI: 10.1161/01.CIR.64.4.760

Other references

Barbieri, D.; Quarentei, G.; Martinscampos, J.V.; Arrudazamith, V., 1965: Celiac Syndrome. Analysis Of Illustrative Cases. Revista Paulista de Medicina 66: 40-58

Stein, K.M., 2008: Noninvasive risk stratification for sudden death: signal-averaged electrocardiography, nonsustained ventricular tachycardia, heart rate variability, baroreflex sensitivity, and QRS duration. Progress in Cardiovascular Diseases 51(2): 106-117

Oehling, A.; Subira, M.L., 1976: Standardization of in vitro methods in the diagnosis of allergic diseases. Various in vitro techniques were studied and it was shown that the hemagglutination and complement fixation tests were the most suitable for diagnosis. Sera were taken from 377 patients with positive intracutaneous reactions to the antigens in que...

Dutta-Gupta, S.; Deshmukh, R.; Venu Gopal, A.; Martin, O.J.F.; Dutta Gupta, S., 2012: Coherent perfect absorption mediated anomalous reflection and refraction. We show bending of light on the same side of the normal in a free-standing corrugated metal film under bidirectional illumination. Coherent perfect absorption (CPA) is exploited to suppress the specular zeroth order leading to effective back-bendi...

Aldrich, J.E., 1984: Nova Scotia's pioneers in radiology. Canadian Medical Association Journal 131(4): 376-380

Tokutomi, S.; Yamamoto, K.T.; Miyoshi, Y.; Furuya, M., 1982: Photoreversible changes in pH of pea phytochrome solutions. Photoinduced pH changes in unbuffered pea phytochrome sol. were studied at 10 degrees C by using a glass electrode. Red light irradiation caused alkalinization of the sol. in pH range 5.2-7.5 and acidification at pH 7.5-8.9. The pH changes were fu...

Simchen, H., 1964: Consequences and problems of plant protection with chemicals in the German Democratic Republic. The development, present status and potential of herbicides in E. Germany are critically reviewed with reference to their economic significance in E. German agriculture and to chemical weed control techniques in other countries. Though demand for...

Ristanovic, M.; Ristanovic, B., 1970: Some biochemical properties of P. prunicola. Observations on the effect of C, N and amino acids on growth in vitro and of the oxidation and reduction properties of P. prunicola.

Hwang, H-Jung.; Kim, I-Hye.; Nam, T-Jeong., 2012: Polysaccharides from Capsosiphon fulvescens stimulate the growth of gastrointestinal cells. Capsosiphon fulvescens is a green alga that is abundant along the southwest coast of South Korea. Although it is consumed for its purported health-enhancing properties, particularly as a treatment for stomach disorders and hangovers, the health ef...

Gubskiy, Yu, I.; Goryushko, G.G.; Litvinova, N.V.; Primak, R.G.; Kurskaya, N.M.; Shnurko, E.V.; Sachenko, L.G., 1999: Antioxidative properties and membranotropic action of some 1,4-dihydropyridine derivatives. Interaction of alpha-tocopherol and 1,4-dihydropyridine with endoplasmic reticulum membranes and model systems, human serum albumin and phospholipid bilayer, was studied using the microcalorimetry and fluorescent probes procedures. Dependence of m...