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Cell survival over the depth profile after irradiation with a negative pion beam

, : Cell survival over the depth profile after irradiation with a negative pion beam. Radiation & Environmental Biophysics 16(3): 267-272

The colony-forming ability of Chinese hamster fibroblast cells [19/1 subline] in vitro was investigated throughout the depth dose profile of a negative pion beam. In the peak and 2 cm beyond, the RBE [relative biological effectiveness] for macroclones (> 50 cells per clone) was 1.3 and in the plateau region 0.8-1.0. All of the microclones (2-49 cells per clone) were observed as well. The RBE values are the same for peak and somewhat higher for plateau and post peak than found in cell survival studies referring to macroclones.


PMID: 504556

DOI: 10.1007/bf01358288

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