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Changes in the metabolism of 7 12 di methyl benz a anthracene under the effect of vitamin a


, : Changes in the metabolism of 7 12 di methyl benz a anthracene under the effect of vitamin a. Byulleten' Eksperimental'noi Biologii i Meditsiny 83(5): 579-582

In vitro metabolism of the carcinogen 7,12-dimethylbenz(a)anthracene [DMBA] by liver microsomes and liver and mammary homogenates of rats, on vitamin A-enriched diets, was studied. Vitamin A inhibited the formation of lipophilic metabolites and increased the generation of water-soluble metabolites. The amount of lipophilic metabolites extracted from the microsomes and liver and mammary homogenates was decreased by a factor of 2.2 and 5, respectively. The amount of unmetabolized DMBA in liver microsomes was the same in control and experimental animals.

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