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Chemotherapy and radiotherapy in advanced testicular non-seminoma. 2. Results of treatment


, : Chemotherapy and radiotherapy in advanced testicular non-seminoma. 2. Results of treatment. RadioTherapy and Oncology 1(3): 207-215

Between 1976 and 1981, 63 patients with Stage II-IV testicular non-seminoma were treated by chemotherapy [vinblastine, bleomycin, cis-platinum and etoposide] followed 4-6 wk later by involved field radiotherapy. Of this group, 58 (92.1%) are alive and tumor free, one patient died post-operatively and four of uncontrolled disease. There were no deaths from drug-induced neutropenic sepsis. During the same period a 2nd group of 53 patients who had received radiotherapy were given chemotherapy for recurrent disease. Of this group, 38 (71.7%) are alive and tumor-free, 8 died of uncontrolled malignancy, 6 from drug-related complications and 1 from a myocardial infarct. In patients receiving elective post-chemotherapy irradiation, tumor volume exerted little influence on treatment outcome, the disease-free survival rates for small volume and bulky disease being 100% and 87.2%, respectively. In patients receiving chemotherapy after prior irradiation there was a significant difference; 96.7% and 43.4%, respectively (P < 0.001). Of the 63 patients in the drug-irradiation protocol group 23 (36.5%) had residual masses excised. In 18 patients (78.2%) the excised tissue showed either fibrosis or mature teratoma. Despite the excellent survival figures for patients receiving post-chemotherapy irradiation the value of this approach cannot be assumed, although the slight difference between small and bulky presentations suggests that radiotherapy may have contributed to the therapeutic result.

US$29.90

PMID: 6505257


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Gers, S.; Potgieter, C.; Wright, I.; Peyrot, B., 2016: Natural Bluetongue virus infection in alpacas in South Africa. NlmCategory="UNASSIGNED">Bluetongue virus (BTV) was sporadically isolated over a four year period (2010-2014) from several alpaca carcasses that were presented for necropsy at the Western Cape Provincial Veterinary Laboratory, South A...

Wilkinson, A.; Parker, M.; Martineau, F.; Leach, M., 2017: Engaging 'communities': anthropological insights from the West African Ebola epidemic. The recent Ebola epidemic in West Africa highlights how engaging with the sociocultural dimensions of epidemics is critical to mounting an effective outbreak response. Community engagement was pivotal to ending the epidemic and will be to post-Ebo...

Mohammed, D.K.; Lavie, O.; de B Lopes, A.; Cross, P.; Monaghan, J.M., 2000: A clinical review of borderline glandular cells on cervical cytology. To review the diagnoses and diagnostic pathway of women presenting with borderline glandular cells on cervical cytology. To outline the basis of clinical approach of these women. Retrospective review. Forty-three women referred to the hospital dep...

Bonneau, J.; Dumestre-Perard, C.; Rinaudo-Gaujous, M.; Genin, C.; Sparrow, M.; Roblin, X.; Paul, S., 2015: Systematic review: new serological markers (anti-glycan, anti-GP2, anti-GM-CSF Ab) in the prediction of IBD patient outcomes. Traditionally, IBD diagnosis is based on clinical, radiological, endoscopic, and histological criteria. Biomarkers are needed in cases of uncertain diagnosis, or to predict disease course and therapeutic response. No guideline recommends the detec...

Lambrecht, Kalman, 1933: Handbuch der Palae-ornithologie. A comprehensive, critical, and fully documented account of fossil birds, based upon both the literature and the author's study of the material in European museums. I. An introduction (pp.4-57) treats of avian osteology, with a classified bibl...

Hoebers, L.P.; Tijssen, J.G.P.; Henriques, Jé.P.S., 2014: Preventive angioplasty in myocardial infarction. New England Journal of Medicine 370(3): 281-281

Murayama N.; Miki K.; Ito S.; Ogawa H., 1988: Oral representation by mechanoreceptive neurons at rat cerebral cortex. Journal of the Physiological Society of Japan 50(8-9): 513

Qureshi, H.; Ahmed, W.; Zuberi, S.J., 1996: Triple therapy in duodenal ulcer healing--a follow up study. Thirty-nine Helicobacter pylori (HP) positive chronic duodenal ulcer patients completed the 4 weeks treatment of triple therapy (Denol, Metronidazole and Amoxil). Of these 29 showed healed duodenal ulcer and negative CLO test at 8 weeks (eradicati...

Mernild Sebastian H.; Hasholt Bent; Liston Glen E., 2008: Climatic control on river discharge simulations, Zackenberg River drainage basin, northeast Greenland. A spatially distributed, physically based, hydrologic modeling system (MIKE SHE) was applied to quantify intra- and inter-annual discharge from the snow and glacierized Zackenberg River drainage basin (512 km (super 2) ; 20% glacier cover) in nort...

Hopper, D.J.; Jones, M.R.; Causer, M.J., 1985: Periplasmic location of p-cresol methylhydroxylase in Pseudomonas putida. The cellular location of the flavocytochrome c, p-cresol methylhydroxylase was investigated in two strains of Pseudomonas putida. In both cases the enzymes were shown to be located in the periplasmic fraction by their release during treatment of t...