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Cholinergic transmission regulates extrajunctional acetyl choline receptors

, : Cholinergic transmission regulates extrajunctional acetyl choline receptors. Experimental Neurology 70(3): 690-696

To determine the role of ACh [acetylcholine] transmission in the regulation of extrajunctional ACh receptors, the effect of postsynaptic cholinergic blockade was compared with that of surgical denervation. Blockade of ACh transmission was produced in the soleus muscles of rats by continuous local infusion of .alpha.-bungarotoxin [.alpha.-BuTx] delivered by implantable osmotic pumps. Extrajunctional ACh receptors were measured by an 125I-.alpha.-BuTx binding method. There was an increase of extrajunctional ACh receptors quantitatively equivalent to that resulting from surgical denervation. This denervation-like effect is attributed to elimination of impulse-dependent ACh transmission (which normally triggers muscle usage), and spontaneous quantal and nonquantal ACh transmission. The influence of the nerve in regulating extrajunctional ACh receptors appears to be due to the sum of these forms of ACh transmission.


PMID: 6254793

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