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Circadian course of body temperature and the excretion of methoxyhydroxyphenyl glycol and vanillyl mandelic acid in a patient with bi polar depression


, : Circadian course of body temperature and the excretion of methoxyhydroxyphenyl glycol and vanillyl mandelic acid in a patient with bi polar depression. Journal of Neural Transmission 53(2-3): 213-216

A 38-yr-old woman with a bipolar affective disorder was examined for 10 days during a serious retarded depression phase and for 10 days during the subsequent symptom-free interval. During depression the MHPG (methoxyhydroxyphenylglycol) excretion showed a significantly shorter circadian periodicity of 20.5 h, whereas the periodicity of body temperature and VMA (vanillylmandelic acid) amounted to 24 h. During the symptom-free interval the circadian periodicity of all parameters was 24 h. The depression phase of a bipolar affective disorder in this patient is related to a desynchronization of central NA (norepinephrine) function with peripheral NA activity and body temperature.

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