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Circadian d2 and mach receptor rhythms and gaba contents in the rat caudate putamen


, : Circadian d2 and mach receptor rhythms and gaba contents in the rat caudate putamen. Neurosciences 13(2): 271-273

D2 receptors, muscarinic acetylcholine (mAch) receptors, and GABA contents were measured in the caudate-putamen of rats (9, 65 weeks), at the six time points during a 12 hour light-dark cycle. Especially about D2 receptors, the differences of specific binding under different ion conditions (100 mM Na+; low affinity sites, 10 mM Mg2+; high affinity sites) were investigated. While significant circadian rhythms by one-way ANOVA were not shown, D2 (both high and low) and mAch receptors in 9 weeks aged groups took high value during mid-dark to mid-light points. Their (max/min) ratios were, 123% in D2-low, 148% in D2-high, and 112% in mAch. It suggests the circadian rhythms of dopamine and acetylcholine systems are synchronized with the multiple unit activities of the caudate-putamen (Inoue et al 1979) or the rat actogram. The levels and rhythms of D2 and mAch receptors were lowered and flattened in 65 weeks aged groups. GABA contents showed a significant circadian rhythm, which took high values at the light phase. It corresponds the inhibitory functions of GABA neurons to such excitatory functions of dopamine, and acetylcholine systems in terms of circadian rhythms.

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