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Circadian rhythm of 3h verapamil binding in the rat hippocampus


, : Circadian rhythm of 3h verapamil binding in the rat hippocampus. Neurosciences 13(2): 274-276

Specific binding of 3H-verapamil in the rat punched-out hippocampus was studied in the circadian aspects under different ionic (Na+ or Mg2+) conditions. The amount of dopamine and serotonin released ([DOPAC + HVA], [5HIAA]:pmoles/mg proteins) were measured in the same brain preparation. 3H-verapamil binding showed a significant and proper circadian rhythms according to the ionic conditions. Under these assay conditions, active temporal position of specific 3H-verapamil binding was investigated through the dark phase (Na+:peak at the mid of the dark phase; Mg2+:biphasic peak at the beginning and the late of the dark phase) was observed, with an exception of no metal ion condition. These results suggested that each Na+ and Mg2+ may distinguish different subclasses of the Ca2+ channel. An analogous circadian rhythms (peak at the mid dark) were observed in the monoaminergic activities. Such a synchronus temporal regulation of these activities suggested some cooperative participation between Ca2+ channel and monoamine metabolism.

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