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Clinical management of tinea corporis cruris and tinea pityriasis versicolor two to three week treatment with bifonazole 1 percent

, : Clinical management of tinea corporis cruris and tinea pityriasis versicolor two to three week treatment with bifonazole 1 percent. Advances in Therapy 3(6): 272-280

A double-blind, randomized, placebo comparison was undertaken to assess once-daily application of bifonazole 1% solution-an azole antimycotic that is highly concentrated by the stratum corneum-in a three-week treatment of 30 patients with tinea corporis/cruris and a two-week treatment of 32 patients with tinea (pityriasis) versicolor. The etiologic agent of tinea corporis/cruris in over 90% of patients was Trichophyton rubrum. The organism tended to induce disease of moderate severity in 57% to 75% of cases and the duration of the disease typically exceeded 12 months. Patients were divided into demographically and medically equivalent treatment groups. They were examined once a week during treatment and at two weeks post treatment; at these points any changes in the patients' clinical or mycological status were documented. An overall response rate was tabulated by determining the patients' level of clinical response in combination with the frequency of KOH or culture conversion. Among patients with tinea corporis/cruris, a striking difference favoring bifonazole over placebo appeared, with overall response rates of 100% and 31%, respectively (p < 0.01). Similar differences favoring bifonazole were also observed among patients with tinea (pityriasis) versicolor, 100% of whom responded to treatment (p < 0.01). No irreversible adverse reactions were reported by any patients in this study.


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Koletic I., 1957: The collared turtle dove streptopelia decaocto in posavski bregi. Larus (English Translation) 9-10: (1973)

hrétien, J.; Dufat, R.; Lemoine, J.M., 1970: Bronchoscopic study of 649 patients with chronic pleurisy. Les Bronches 20(1): 41-73

Kattermann, G., 1934: Cytoiogical notes on wheat-rye hybrids. Crosses were made between a number of varieties of Triticum vulgare and one of 2". durum with varieties of Secale cereale and hybrids were obtained from three crosses. Backcrosses were made to the parents and three plants, one from a rye back...

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