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Core particles of hepatitis b virus and ground squirrel hepatitis virus 2. characterization of the protein kinase reaction associated with ground squirrel hepatitis virus and hepatitis b virus


, : Core particles of hepatitis b virus and ground squirrel hepatitis virus 2. characterization of the protein kinase reaction associated with ground squirrel hepatitis virus and hepatitis b virus. Journal of Virology 43(2): 741-748

The recently described protein kinase activity in hepatitis B virus core antigen particles has been demonstrated in the liver-derived core particles of ground squirrel hepatitis virus. Both protein kinase activities were initially associated with DNA polymerase-positive heavy core particles in CsCl density equilibrium gradients and shifted to polymerase-negative cores during the course of purification. The major core-associated polypeptide of each virus was the dominant species labeled. A variable number of other polypeptide species were also labeled by this reaction. Tryptic peptide mapping of both major and minor phosphorylated polypeptides of each virus resulted in similar patterns, suggesting that many of the sites of phosphorylation were the same in the components of each core particle. Hydrolysis of these phosphorylated core particles revealed a major phosphoamino acid as serine and a minor phosphoamino acid as threonine. The products of the protein kinase reaction in both human hepatitis B and ground squirrel hepatitis virus core particles, then, share many characteristics. The possible function(s) of this protein kinase activity is discussed in the light of similarly characterized activities in other animal viruses.

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PMID: 7109041


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