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Cytosol and nuclear estrogen receptor in the genital tract of the rhesus monkey


, : Cytosol and nuclear estrogen receptor in the genital tract of the rhesus monkey. Journal of Steroid Biochemistry 8(2): 151-155

Estrogen receptor levels of cytosol and nuclei were measured in the cervix, vagina, myometrium and endometrium of the rhesus monkey after the following experimental treatments: castration; castration with estradiol treatment; and castration with estradiol [E2] plus progesterone treatment. Plasma hormone levels similar to those of normal menstrual cycles were achieved by implantation of silastic capsules containing estradiol or progesterone. The Kd 4 .times. 10-9 M, for the cytosol receptor was similar in all tissues. Competition studies showed cytosol receptor affinities to be E2 > E1 [estrone] > E3 [estriol] > DES [diethylstilbestrol]. Cytosol receptor levels in estrogenized animals were lowered by progesterone treatment. Progesterone treatment did not alter the levels of nuclear receptor, indicating that the lower levels of cytosol receptor obtained with progesterone were not due to nuclear translocation of cytosol receptor. Estrogen treatment changed the sedimentation coefficient of the endometrial and myometrial cytosol receptor from 4 s to 8 s when compared with the castrate. This alteration in sedimentation coefficient was blocked by progesterone treatment. Changes in sedimentation coefficient were not observed in the cervix or vagina. Nuclear receptor in estrogen and estrogen plus progesterone treated animals sedimented as a 5 s protein. Both qualitative and quantitative changes in the estradiol cytosol receptor of the genital tract are probably induced by progesterone, and these alterations may be related to the hormone interactions in target organs.

US$19.90

PMID: 405533

DOI: 10.1016/0022-4731(77)90039-5


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