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Derivatives of tritium labeled serotonin in organ cultures of hamster pineal gland

, : Derivatives of tritium labeled serotonin in organ cultures of hamster pineal gland. Life Sciences 34(18): 1775-1782

The viability of the hamster pineal gland in organ culture was determined, and the effect of norepinephrine (NE) on [3H] serotonin derivatives was tested. In this study, elevated levels of melatonin (7-fold, P < 0.05), 5-hydroxytrytophol (5-fold, P < 0.001), 5-methoxytryptophol (1.78-fold, P < 0.05) and depressed levels of 5-hydroxyIAA (3.8-fold, P < 0.02) and methoxyIAA (1.78-fold, P < 0.05) were detected in the glands following the addition of NE to the medium. In a separate experiment, melatonin concentration in the media was also periodically measured by radioimmunoassay to determine the viability of the organ culture over a 4-day period. The melatonin level on day 2 (2321 .+-. 106 pg/gland) was significantly higher (P < 0.01) than on day 3 (1542 .+-. 86 pg/gland) or day 4 (805 .+-. 39 pg/gland). The viability of the hamster pineal organ culture was verified and it was shown that the gland responds to NE in vitro.


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