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Determination of busulfan in plasma by gas chromatography mass spectrometry with selected ion monitoring


, : Determination of busulfan in plasma by gas chromatography mass spectrometry with selected ion monitoring. Journal of Pharmaceutical Sciences 72(10): 1203-1205

A GC-MS [gas chromatography/mass spectrometry] technique with selected-ion monitoring is described for the determination of busulfan [an antineoplastic drug] in plasma. Busulfan is extracted from plasma with methylene chloride and converted to 1,4-diiodobutane. Analysis by GC-MS with selected-ion monitoring (m/z 183) gave a relative SD of .+-. 4.3% (n = 5) at the 10-ng/ml level.

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