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Development of wet dog shakes during amygdala kindling in the rat


, : Development of wet dog shakes during amygdala kindling in the rat. Experimental Neurology 70(3): 487-497

Repeated electrical stimulation of the amygdala in the rat is associated with an increasing incidence of recurrent shaking, tremors of the head, neck and trunk, known as wet dog shakes. Wet dog shakes occur only following stimulations evoking afterdischarge activity and are also related to behavioral seizure stage. They have a precise time of onset (83 .+-. 2 s) after amygdala stimulation. In a preliminary series of acute drug challenges, clonidine and diazepam (but not naloxone, pimozide, cocaine and dexamethasone) blocked these behaviors. The emergence of wet dog shakes during amygdala kindling may be associated with the release of an endogenous neurotransmitter of peptide.

US$19.90

PMID: 7439288

DOI: 10.1016/0014-4886(80)90175-2


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