geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Dexamethasone suppression test in severe schizophrenic illness: effects of plasma dexamethasone and caffeine levels


, : Dexamethasone suppression test in severe schizophrenic illness: effects of plasma dexamethasone and caffeine levels. Acta Psychiatrica Scandinavica 75(6): 608-613

A dexamethasone suppression test (DST) was administered to 31 inpatients with a severe acute achizophrenic exacerbation 4 or 5 days following admission and repeated after 4' weeks or prior to discharge. We identified 15 patients (48%) who were nonsuppressors on the DST at the first test. To exclude major confounders of DST results we monitored weight constancy and plasma concentrations of dexamethasone. In a subgroup of patients also plasma caffeine contents were determined. Our results indicate that DST nonsuppression occurs frequently among patients with schizophrenic crisis. Since caffeine plasma levels were indistinguishable between suppressors and nonsuppressors we reject that excessive caffeine intake accounts for DST nonsuppression among individuals with schizophrenia. Nonsuppressors had lower plasma dexamethasone levels than suppressors and reversal of the DST status from nonsuppression to suppression was associated with an increase of plasma concentrations of the test drug.

US$29.90

PMID: 3618283


Other references

Vidailhet, M.; Bonnet, A.M.; Agid, Y., 1998: Clinical diagnostic criteria for multiple system atrophy. What are the distinctive criteria for the diagnosis of multiple system atrophy? The combination of motor, dysautonomic, neuropsychological and eyes movements may help to distinguish, at a early stage, multiple system atrophy from other neurodegene...

Pena, A.; Carmona, A.; Barbosa, A.; Lino, C.; Silveira, I.; Castillo, B., 1999: Determination of tetracycline and its major degradation products by liquid chromatography with fluorescence detection. A liquid chromatographic method of tetracycline and its major degradation products on a C8-reversed phase column with acidic mobile phase and fluorescence detection is described. The quantification limit, measured as the amount of sample that gave...

Kato, Y.; Igarashi, H.; Kanno, H.; Sakagami, K.; Hirokawa, H.; Tanaka, K.; Yoshida, A., 1997: Organophosphate metabolic lens changes caused by ultraviolet radiation. Investigative Ophthalmology & Visual Science 38(4 PART 1-2): S1019

Rice, CG., 1984: The behavior and ecology of Nilgiri tahr (Hemitragus hylocrius Ogilby, 1838). Dissertation Abstracts International B Sciences and Engineering, 455: 1369

Kiy, A.Maria.; Rugolo, L.Maria.Suppo.de.Souza., 2016: Author's reply: Maternal hypertension and infant growth. Jornal de Pediatria 91(6): 604-605

Lang I.; Marsh J.; Olman M.; Moser K.M., 1990: Identification of a plasminogen activator inhibitor in dogs that cross reacts with human pai 1 antibodies. American Review of Respiratory Disease 141(4 PART 2): A99

Giro, L., 1950: Two cases of pulmonary tuberculosis. L' Homeopathie Francaise 26(5): 298-304

Fries, W.W.lker, R., 1981: The use of a two bed (acrylic and styrenic) strong base ion exchange system for the decolorization of cane sugar liquors. Proceedings of the Technical Session on Cane Sugar Refining Research USDA Science and Education Administration: ub 1981) 171-181

Jin, Z.E.L.; Sh.L.; Hua, L.U, 2011: How Has the Wenchuan Earthquake Influenced Peoples Intertemporal Choices?. On May 12, 28, a major magnitude-8. earthquake shook Wenchuan, China. An opportunity sample of 14 college students was obtained to conduct a within-subject study investigating the influence of the earthquake on intertemporal choices. The findings...

Haas, H.; Strenzke, K., 1957: Experimentelle Untersuchungen uber den Einfluss der ionalen Zusammen-setzung des Mediums auf die Entwicklung der Tubuli von Chironomus thummi. Biologisches Zentralblatt Leipzig, 76: 486-509