+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Distribution of fibronectin and laminin in human liver tumors

, : Distribution of fibronectin and laminin in human liver tumors. Journal of Cancer Research & Clinical Oncology 109(1): 60-64

Two extracellular matrix and basement-membrane components, fibronectin (Fn) and laminin, were studied by the indirect immunoperoxidase technique in 6 primary human liver cancers. Similar distributions of both Fn and laminin were detected in the well differentiated hepatocellular carciomas with trabecular and tubular pattern. Two moderately differentiated hepatomas contained Fn only. Neither Fn nor laminin were present in the parenchyma of one poorly differentiated hepatoma. In 3 cases of cholangiocarcinoma, laminin surrounded the tumorous ducts, while Fn appeared mainly in the reactive connective tissue stroma. Bile-duct cancers synthetize laminin, and not Fn while differentiated hepatocellular carcinomas produce both Fn and laminin in vivo. The presence of Fn even in moderately differentiated types of liver cancer is in contrast to the findings for carcinomas developing from other organs and it may serve as a marker for primary hepatocellular carinomas in the differential diagnosis.


PMID: 2982880

DOI: 10.1007/bf01884256

Other references

Antonic, A.; Sena, E.S.; Donnan, G.A.; Howells, D.W., 2012: Human in vitro models of ischaemic stroke: a test bed for translation. Translational Stroke Research 3(3): 306-309

de Melo, Nália.Bandeira.; Dos Santos, Lícia.Fernanda.Moreira.; de Castro, M.Santos.; Souza, R.Lopes.Martins.; Marques, M.José.; Castro, A.Pereira.; de Castro, Aísa.Teixeira.; de Carli, M.Lara.; Hanemann, Jão.Adolfo.Costa.; Silva, M.Siqueira.; Moraes,; Beijo, L.Alberto.; Brigagão, Mísa.Ribeiro.Pereira.Lima.; Sperandio, F.Fornias., 2017: Photodynamic therapy for Schistosoma mansoni: Promising outcomes. The purpose of this study was to assess, for the very first time, the effects of photodynamic therapy (PDT) on Schistosoma mansoni in vitro by measuring reactive oxygen species (ROS) generation throughout the treatment, as well as the behavior of...

French, A.M.; Scott, N.C., 1978: The antiarrhythmic effects of a benzotriazinium salt in mice and guinea-pigs [proceedings. British Journal of Pharmacology 64(3): 398p-398p

Hafeez, M.; Avsatthi, BL., 1985: In vitro maintenance of Paramphistomum epiclitum (Trematoda: Paramphistomidae). Gujvet, 141-2: 9-11

Yan, Qing Shan, 2000: Activation of 5-HT2A/2C receptors within the nucleus accumbens increases local dopaminergic transmission. This study was designed to assess the involvement of the 5-hydroxytryptamine (5-HT)2A/2C receptor subtypes in the regulation of in vivo dopamine release in the rat nucleus accumbens (NAC). Extracellular dopamine (DA) in the NAC was measured using...

Silverman, J.B.; Restituito, S.; Lu, W.; Lee-Edwards, L.; Khatri, L.; Ziff, E.B., 2007: Synaptic anchorage of AMPA receptors by cadherins through neural plakophilin-related arm protein AMPA receptor-binding protein complexes. Cadherins function in the adhesion of presynaptic and postsynaptic membranes at excitatory synapses. Here we show that the cadherin-associated protein neural plakophilin-related arm protein (NPRAP; also called delta-catenin) binds via a postsynap...

Xie, C.; Guo, H.; Wu, Z.; Guo, Y.; Gao, Y.; Yuan, J.; Gu, Z., 2013: Optimization of high-quality dietary fiber production in submerged fermentation by Agrocybe chaxingu. The aim of this study was to determine the optimal conditions for high-quality dietary fibre (DF) production by <em>Agrocybe chaxingu</em> in a submerged culture fermentation system of wheat bran. The substances which may affect DF qua...

McPHERSON.D., 1954: Canadian Association of Medical Record Librarians. Canadian Hospital 31(12): 47-47

Benjamin H.; Storkson J.M.; Albright K.; Pariza M.W., 1990: Tpa mediated induction of ornithine decarboxylase activity in mouse forestomach and its inhibition by conjugated dienoic derivatives of linoleic acid. FASEB Journal 4(3): A508

Jurkojć, J.; Wodarski, P.; Michnik, R.; Nowakowska, K.; Bieniek, A.; Gzik, M., 2017: The Upper Limb Motion Deviation Index: A new comprehensive index of upper limb motion pathology. The aim of the research was to formulate a new index enabling assessment of the overall pathology of the upper limb movement. It defines the difference between the pathological movement and a normal movement pattern. Methodology of determining the...