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Distribution of fibronectin and laminin in human liver tumors


, : Distribution of fibronectin and laminin in human liver tumors. Journal of Cancer Research & Clinical Oncology 109(1): 60-64

Two extracellular matrix and basement-membrane components, fibronectin (Fn) and laminin, were studied by the indirect immunoperoxidase technique in 6 primary human liver cancers. Similar distributions of both Fn and laminin were detected in the well differentiated hepatocellular carciomas with trabecular and tubular pattern. Two moderately differentiated hepatomas contained Fn only. Neither Fn nor laminin were present in the parenchyma of one poorly differentiated hepatoma. In 3 cases of cholangiocarcinoma, laminin surrounded the tumorous ducts, while Fn appeared mainly in the reactive connective tissue stroma. Bile-duct cancers synthetize laminin, and not Fn while differentiated hepatocellular carcinomas produce both Fn and laminin in vivo. The presence of Fn even in moderately differentiated types of liver cancer is in contrast to the findings for carcinomas developing from other organs and it may serve as a marker for primary hepatocellular carinomas in the differential diagnosis.

US$19.90

PMID: 2982880

DOI: 10.1007/bf01884256


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