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Distribution of glutamate decarboxylase in discrete brain nuclei


, : Distribution of glutamate decarboxylase in discrete brain nuclei. Brain Research 108(2): 371-379

The L-glutamate decarboxylase (GAD) levels of 70 rat brain nuclei were determined. The distribution of GAD was uneven. High GAD activity was found in the substantia nigra, the colliculi, some hypothalamic nuclei (e.g., dorsomedial), some nuclei of the limbic system (e.g., tractus diagonalis and accumbens) and the medial forebrain bundle. The reticular part of the substantia nigra had the highest activity, 2-fold higher than any other nucleus. Low GAD activity was found in the nuclei of the pons, the hypothalamic median eminence and the reticular formation. Moderate activity was measured in most areas studied. The biochemical mapping of GAD is discussed in relation to possible GABA pathways in the brain.

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PMID: 1276902


Other references

Andre, M.; Henry Amar, M.; Pico, J.L.; Bastion, Y.; Blaise, D.; Kuentz, M.; Colombat, P.; Cahn, J.Y.; Attal, M.; Fleury, J.; Milpied, N.; Biron, P.; Nedellec, G.; Jouet, J.P.; Tilly, R.; Ferme, C.; Gisselbrecht, C., 1996: Autologous stem cell transplantation improves survival of refractory Hodgkins disease patients A retrospective match-controlled study. Blood 88(10 SUPPL 1 PART 1-2): 123A

Canciullo, D.; Silimbani, A., 1956: Considerations on salivary urea. L'oto-Rino-Laringologia Italiana 24(2): 155-162

Anonymous, 1989: Hill-Burton compliance remains a problem. Hospital Law Newsletter 6(10): 5-7

Groothuis, P.G.; D.G.oyer, M.E.; ten Kate, J.; Menheere, P.P.; Dunselman, G.A.J.; de Goeij, A.F.P.M.; Verbost, P.; Ederveen, A.G.H.; Kloosterboer, H.J., 2006: Tibolone and metabolites induce prolactin production in human endometrial stromal cells in vitro: evidence for cell-specific metabolism. In this study, we assessed the effects of tibolone and its metabolites on the production of a progesterone sensitive parameter, prolactin, in human endometrium stroma cells in vitro. In addition, the metabolism of the compounds by isolated stromal...

Moreira, K.E.; Walther, T.C.; Aguilar, P.S.; Walter, P., 2008: Pil1 controls eisosome biogenesis. The molecular composition of plasma membranes is constantly remodeled by endocytosis and exocytosis. Eisosomes are large cytoplasmic protein assemblies that localize to specialized domains on the yeast plasma membrane. They are of uniform size and...

D.Bisceglie, A.M., 1998: Hepatitis C. Lancet 351(9099): 351-355

Roda, A.; Sabatini, L.; Mirasoli, M.; Baraldini, M.; Roda, E., 2002: Bioavailability of a new ketoprofen formulation for once-daily oral administration. A new sustained-release formulation (sustained release Ibifen(R)) that gradually releases ketoprofen within 24 h and ensures therapeutic plasma concentration for the entire period has been developed. It consists of tableted pH-dependent barrier fi...

Paskov, G., 1977: Promising sprinkler installations for forest tree nurseries. Gorsko stopanstvo: 33 (11) 52-54

Chen, Y-Guang.; Chang, H-Ming.; Chen, Y-Lin.; Cheng, Y-Chiao.; Hsu, C-Hui., 2011: Perforated acute appendicitis resulting from appendiceal villous adenoma presenting with small bowel obstruction: a case report. A villous adenoma is an extremely rare benign tumour in the appendix, in contrast to other benign appendiceal lesions. The clinical features are usually asymptomatic. Acute appendicitis is the most common complication with the lesion obstructing t...

Sakai Y.; Yamamoto N.; Yasuda K., 1977: Localization of hyaluronidase in the testis of sheep. Acta Histochemica et Cytochemica 10(1): 146