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Effect of 3 4 diaminopyridine on the contractions of guinea pig tracheal smooth muscle induced by histamine and prostaglandin d 2

, : Effect of 3 4 diaminopyridine on the contractions of guinea pig tracheal smooth muscle induced by histamine and prostaglandin d 2. Folia Pharmacologica Japonica 91(2): 90-96

Effects of 3,4-diaminopyridine (DAP), which decreases the membrane K conductance, on the contractions of guinea-pig tracheal smooth muscle induced by histamine and prostaglandin D2 (PGD2) were investigated. Pretreatments with 5 .times. 10-4 and 10-3 M DAP increased the exitability of histamine-induced contraction. The increment of the excitability by DAP was not suppressed by tetrodotoxin (TTX), but by nifedipine (Nif). Pretreatment with 10-3 M DAP did not affect the contraction induced by PGD2. The results suggest that DAP increases the excitability of histamine-induced contraction by activating the voltage-dependent Ca channels and that PGD2 contracts tracheal smooth muscle through a mechanism different from that of histamine.


PMID: 3163668

Other references

Leigh, G.; Holman, T.; Burr, W., 1987: Some confusions and exclusions of the SVR theory of dyadic pairing: a response to Murstein. Journal of marriage and the family 49(4): 933-937

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Wong, J.M.Y.; Kyasa, M.J.; Hutchins, L.; Collins, K., 2004: Telomerase RNA deficiency in peripheral blood mononuclear cells in X-linked dyskeratosis congenita. Compromised renewal and eventual failure of the hematopoietic system in dyskeratosis congenita (DC) have been proposed to arise from a deficiency in telomerase function. Previously, cultured cell lines from patients with X-linked DC were shown to...

Takahashi, S.; Futaki, N.; Yokoyama, M.; Yamakawa, Y.; Arai, I.; Higuchi, S.; Otomo, S., 1994: Expression of cyclooxygenase-2 in endotoxin shock rats. Japanese Journal of Pharmacology 64(SUPPL 1): 94P

Pourcyrous M.; Bada H.S.; Korones S.B.; Wong S.P., 1992: Evaluation of the sensitivity of urine streptococcal latex agglutination test in neonatal group b streptococcal septicemia. Pediatric Research 31(4 PART 2): 217A

Steele Kathy B.; Colquhoun Donald J.; Hazel Joseph E., 1988: Depositional environments in the middle Eocene Orangeburg Group, Savannah River Plant area, South Carolina. Abstracts with Programs - Geological Society of America 20(4): 317

Pless, I.B., 2006: WHO's Plan of Action. Injury Prevention 12(4): 209-209

Van Der Lee, R.; Pfaffendorf, M.; Van Zwieten, P.A., 1999: Effect of mibefradil and verapamil on electrical field stimulation-induced contractions in the rat tail artery. British Journal of Pharmacology 126(PROC SUPPL ): 57P, March

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