+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of amiodarone on coronary reperfusion induced ventricular arrhythmias in dogs

, : Effect of amiodarone on coronary reperfusion induced ventricular arrhythmias in dogs. Taiwan yixuehui zazhi 85(12): 1110-1116

To investigate the effects of amiodarone on the ventricular arrhythmias induced by coronary artery reperfusion, 19 dogs were subjected to 30 minutes of left anterior descending (LAD) coronary artery occlusion followed by reperfusion. Nine of these dogs received continuous intravenous infusion of amiodarone (5 mg/kg/hr) for 50 minutes starting from 10 minutes before LAD occlusion until 10 minutes fter reperfusion. The remaining 10 dogs received saline infusion and served as control. The results showed that 9 of the control dogs (90%) had ventricular tachycardia (VT) upon reperfusion while 4 of the amiodarone group (44%) had reperfusion VT (0.02 < P < 0.05). On the other hand, 5 of the control group (50%) and 4 of the amiodarone group (44%) developed reperfusion ventricular fibrillation (VF) (P > 0.05). This dose of amiodarone was shown to slow the canine heart rate significantly. Before the drug was gvien, the heart rate was 176 .+-. 9 bpm (mean .+-. SE). Ten minutes later, just prior to LAD occlusion, the heart rate decreasedto 143 .+-. 16 bpm (0.001 < P < 0.01) and 30 minutes after LAD occlusion, the heart rate further decreased to 110 .+-. 12 bpm (0.001 < P < 0.01). We conclude that amiodarone is ineffective in preventing the perfusion VF, while it decreases significantly the incidence of reperfusion VT in dog.


PMID: 3469318

Other references

Weissauer, W.; Hirsch, G., 1982: The liability of the gynecologist. General review and special problem areas. Der Gynakologe 15(2): 80-88

Anonymous, 2013: Lipid antigens for diverse NKT cells. CD1d-restricted natural killer T (NKT) cells include two major subgroups. The most widely studied are V?14J?18+ invariant NKT (iNKT) cells that recognize the prototypical ?-galactosylceramide antigen, whereas the other major group uses diverse T-c...

Matsuoka, S.; Ogawa, H.; Maki, H.; Yonezawa, Y.; Caldwell, W.Morton., 2012: A new safety support system for wandering elderly persons. We have developed a new mobile phone-based safety support system for transmitting information of a wandering elderly person's location and the environmental sounds around that person. The system consists of a wearable sensor and a conventiona...

Stothard, J.R.ssell; Rollinson, D., 1996: An evaluation of random amplified polymorphic DNA for the identification and phylogeny of freshwater snails of the genus Bulinus. The Random Amplified Polymorphic DNA (RAPD) assay was used to study genetic variation within and between 9 species of the genus Bulinus and to determine whether RAPD profiles could be used as markers for identification purposes. RAPDs were generat...

Margolis, M.G., 1974: Astigmatism. Meditsinskaia Sestra 33(10): 12-15

Ramelet, A.A., 2000: Pharmacologic aspects of a phlebotropic drug in CVI-associated edema. Several phlebotropic drugs, or edema-protecting drugs, are available, the most important of which are found in the gamma-benzopyrone family (flavonoids). gamma-Benzopyrones can be plant extracts, semisynthetic preparations, or synthetic preparatio...

Kim, M.; Lee, K.Woo.; Cho, A.E., 2013: Elucidation of allosteric inhibition mechanism of 2-Cys human peroxiredoxin by molecular modeling. We used molecular dynamics (MD) simulations and protein docking to elucidate the mechanism of allosteric inhibition of the human form of peroxiredoxin (Prx), 2-Cys proliferation associated gene (PAG). Beginning by using the rat form of Prx, 2-Cys...

Ibidapo, C.A., 2005: Prevalence of intestinal helminth parasites of dogs in Lagos, Nigeria. A survey was conducted to determine the prevalence of intestinal helminths in 310 dogs (164 males and 146 females) in Lagos, Nigeria [date not given]. Of them, 175 were pet dogs and were routinely checked by veterinary doctors, while the remaining...

Zhao, G.; A.M.hdi, A.B.; Fisher, A.B., 1997: Different mechanisms for oxidant generation with anoxia-reoxygenation vs ischemia in rat lungs. FASEB Journal 11(3): A127

Zava, D.T.; McGuire, W.L., 1978: Androgen action through estrogen receptor in a human breast cancer cell line. Androgens stimulate the growth of the human breast cancer cell line MCF-7. Very high doses are required, however, and therefore, whether they might exert this effect through some mechanism other than the androgen receptor was studied. Evidence is...