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Effect of brain antibodies on the processes of lipid peroxidation in the brain


, : Effect of brain antibodies on the processes of lipid peroxidation in the brain. Byulleten' Eksperimental'noi Biologii i Meditsiny 99(1): 48-50

The effects of blood serum and IgG fraction from dogs immunized with brain and blood sera from patients with multiple sclerosis and schizophrenia on lipid peroxidation were studied in rat brain homogenates. The content of diene conjugates (DC) and malonic dialdehyde (MDA) were measured in the rat brain after administering the IgG fraction. Antioxidant activity of blood sera and IgG fraction from control animals and donors was significantly higher as compared to experimental. Administration of the IgG fraction brought about an increase in the content of DC and MDA in the brain of experimental animals. Complement-dependent brain antibodies present in the blood serum of patients with schizophrenia and multiple sclerosis potentiate lipid peroxidation in the cerebral tissue and the unsophisticated and informative method for antibody determination may be used in clinical practice.

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