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Effect of captopril on chronic puromycin aminonucleoside nephrosis in rats

, : Effect of captopril on chronic puromycin aminonucleoside nephrosis in rats. Research Communications in Chemical Pathology and Pharmacology 54(2): 279-282

The effect of captopril, an angiotensin converting enzyme inhibitor, on the progression of chronic puromycin aminonucleoside (PAN) nephrosis was examined. Rats were injected with 15 mg/100 gm body weight PAN and 5 mg/100 gm body weight, on weeks-1 and 5, respectively. A third group was injected with an equivalent volume of 0.9% saline, intraperitoneally (Group III) on week -1 and 5. Beginning week 0, group I received 50 mg/kg captopril daily in the drinking water for 12 weeks.


PMID: 3538253

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