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Effect of captopril on the progression of induced pyelonephritis in the rat


, : Effect of captopril on the progression of induced pyelonephritis in the rat. American Journal of Veterinary Research 47(5): 1085-1088

The effect of captopril, an angiotensin-converting enzyme inhibitor, was studied in rats subjected to Escherichia coli pyelonephritis. Eight weeks after pyelonephritis was induced in male Sprague-Dawley rats, the rats were randomly assigned to treatment groups based on urinary protein excretion. In experiment 1, rats were given captopril, 50 mg/kg of body weight, or saline solution via daily intraperitoneal injection. To eliminate complications with captopril-induced peritonitis, experiment 2 was performed in which rats were given the same treatment by daily gavage. In both experiments, 24-hour urinary protein excretion in the saline-treated rats was significantly greater than that of the captopril-treated rats after 12 weeks of treatment (P less than 0.05). Plasma urea nitrogen, plasma creatinine, and endogenous creatinine clearance did not differ between treatment groups during the course of therapy in experiment 1. There were no differences in these values in experiment 2, except at week 8 of treatment when the captopril-treated rats had significantly lower plasma creatinine and higher endogenous creatinine clearance than did the saline-treated rats (P less than 0.05). There was also no difference between treatment groups in the degree of morphologic renal damage based on light microscopic evaluation of kidneys at the end of treatment.

US$29.90

PMID: 3521405


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Koch, T.; Franzke, J., 1964: Metastasierendes Schilddrusenkarzinom bei einem Rotfuchs (Vulpes vulpes). Kleintier-Praxis Hannover, 9: 83-90

Jackson, D.C.; Howlett, G.J.; Nestorowicz, A.; Webster, R.G., 1983: The equilibrium constant for the interaction between a monoclonal Fab fragment and an influenza virus neuraminidase. The affinity or equilibrium constant between an Fab fragment derived from monoclonal IgG directed against influenza virus neuraminidase was measured as 4.1 X 10(7) M-1. The method, which makes use of an air-driven ultracentrifuge, is simple and us...

Loredo Abdala, A.; Lechuga Medina, M.T.; Sandoval Guerrero, R.; Carbajal Rodríguez, L.; Vidales Bayona, C., 1979: Engelmann-Camurati's disease. Report of a clinical case and its evolution during 4 years. Engelmann-Camurati's diseases is a progressive alteration of the diaphysis of the long bones, where the etiology is unknown. It appears clinically around the age of two years, showing weakness of the lower limbs and frequent falls; there is a...

Monosi, A.; Trinci, M., 1966: Astrocytomas of the brain. Clinical and therapeutic considerations. Nuntius Radiologicus 32(8): 839-857

Habibi, B.; Lopez, M.; Salmon, C., 1974: Two new cases of Rh mosaicism. Selective study of red cell populations. Vox Sanguinis 27(3): 232-242

Tscherner, Walter., 2002: Nematodes of the order Spirurida from birds of Berlin Zoo Nematoden der Ordnung Spirurida aus Voegeln des Tierparks Berlin. Milu, 106: 645-653

Szentes Ferenc, 1936: Koevesuelt hullambarazdak; ueber fossile Wellenfurchen. A study of the genesis of various types of ripple marks.

Helm, M.; Hauke, J.; Lampl, L., 2002: A prospective study of the quality of pre-hospital emergency ventilation in patients with severe head injury. Background. Pre-hospital endotracheal intubation for the purpose of controlled ventilation may prevent secondary brain injury in patients with severe head injury. In view of the limited monitoring devices utilized in the pre-hospital setting, litt...

Hervás Puyal, C.; Cavero Cosculluela, L.; Gusiñer Canadell, M.; Pijuán Sabaté, T.; Aguado Santos, S., 1983: Hypoparathyroidism and anesthesia: apropos of 2 cases. Revista Espanola de Anestesiologia Y Reanimacion 30(1): 27-29

Matheson, L.N.; Kane, M.; Rodbard, D., 2002: Development of new methods to determine work disability in the United States. The development of new methods to determine work disability for the United States Social Security Administration is described, including the fiscal and administrative background to the current and proposed methods. An introduction to the current d...