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Effect of ms 932 4 acetylaminophenylacetic acid on delayed type hypersensitivity reaction induced by the influenza virus a kumamoto hemagglutinin in cyclophosphamide treated mice


, : Effect of ms 932 4 acetylaminophenylacetic acid on delayed type hypersensitivity reaction induced by the influenza virus a kumamoto hemagglutinin in cyclophosphamide treated mice. International Journal of Immunotherapy 4(2): 73-78

The effects of MS-932 (4-acetylaminophenylacetic acid) and recombinant interleukin 2 (rIL- 2) on delayed-type hypersensitivity (DTH) reaction induced by the influenza virus A/Kumamoto haemagglutinin were studied in cyclophosphamide (CPD) pretreated mice. MS-932 and rIL-2 significantly suppressed the reaction. The reaction was significantly suppressed in the mice which received a combined administration of each drug at a suboptimal dose. Both drugs increased the percentage of Lyt-23+ cells in the spleens isolated from immunized mice which were pretreated with CPD. Increased IL-2 production was observed in MS-932-treated BALB/c and MRL/Mp-Ipr/Ipr mice. These results suggest that MS-932 suppresses the DTH reaction by enhancing the induction of suppressor T cells by means of IL-2 production.

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