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Effect of pre treatment with bcg on the course of a listeria monocytogenes infection in normal and congenitally athymic nude mice

, : Effect of pre treatment with bcg on the course of a listeria monocytogenes infection in normal and congenitally athymic nude mice. British Journal of Experimental Pathology 57(3): 310-315

The effect of pretreatment with BCG on the course of a L. monocytogenes infection was studied in nu/nu mice and in their heterozygous littermates (+/nu). The nu/nu mice used apparently lacked functional T [thymus derived] cells, since BCG treatment resulted only in skin reactivity to tuberculin in +/nu mice and not in nu/nu mice. Acquired resistance to Listeria (based on lower spleen counts) was only obtained in BCG pretreated +/nu mice. BCG pretreatment in nu/nu mice failed to increase non-specific resistance in terms of spleen counts and survival rate. Functional T cells are apparently required for this type of non-specific resistance to heterologous antigens. Attention is drawn to the possible implication of BCG treatment in man.


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