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Effects of age and sex on ketamine anesthesia in the rat

, : Effects of age and sex on ketamine anesthesia in the rat. British Journal of Anaesthesia 50(9): 885-890

I.p. injections of ketamine 75 mg/kg in rats of both sexes (age 1-16 wk) revealed a significant relationship between increased age and decreased duration of sleeping time for both sexes during the 1st 3 wk of age. This decrease in sleeping time might be associated with the increased production of the cyclohexanone oxidation metabolite of ketamine. After 3 wk of age there was a greater sleeping time in the female rat than the male and this was associated with a greater ability of the male to produce the cyclohexanone oxidation metabolite.


Other references

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Menard Henry W., 1959: Geology of the Pacific sea floor. For the most part, the floor of the Pacific Ocean has a broad reticulate pattern of elevations and depressions, with superimposed deep trenches, linear archipelagos, and fracture zones. Broad smooth abyssal plains have been developed where turbidi...

Napoleao, R.; CafeFilho, A.C.; Lopes, C.A.; Nasser, L.C.B.; Marouelli, W.A., 2007: Effect of watering frequency and soil moisture status on carpogenic germination of Sclerotina sclerotiorum. The effects of watering frequency and soil moisture status on the carpogenic germination of Sclerotinia sclerotiorum were studied under controlled environmental conditions. Soil and sclerotia were placed in gerbox and periodically watered up to 75...

Chida, K.; Konno, H.; Sahara, M.; Takase, S., 1995: Meningeal seeding of spinal cord glioblastoma multiforme without any signs of myelopathy. An autopsy case of meningeal spreading of glioblastoma multiforme (GBM) probably originating in the cervical cord was reported. In contrast to autopsy findings, main symptoms were similar to subacute meningitis, and any signs of myelopathy could n...

Curry, A.; Smith, S.T., 1998: Information on alternative medicine: a collection management issue. Collection management of library materials about alternative medicine may be a growing problem for librarians because differing views exist regarding the acceptability of this information in a public forum. The purpose of the study reported was to...