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Effects of age and sex on ketamine anesthesia in the rat


, : Effects of age and sex on ketamine anesthesia in the rat. British Journal of Anaesthesia 50(9): 885-890

I.p. injections of ketamine 75 mg/kg in rats of both sexes (age 1-16 wk) revealed a significant relationship between increased age and decreased duration of sleeping time for both sexes during the 1st 3 wk of age. This decrease in sleeping time might be associated with the increased production of the cyclohexanone oxidation metabolite of ketamine. After 3 wk of age there was a greater sleeping time in the female rat than the male and this was associated with a greater ability of the male to produce the cyclohexanone oxidation metabolite.

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