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Effects of carrageenan poly vinyl pyrrolidone and tumor bearer serum on immunity induced by excision or mitomycin c treated tumor cells in mice


, : Effects of carrageenan poly vinyl pyrrolidone and tumor bearer serum on immunity induced by excision or mitomycin c treated tumor cells in mice. British Journal of Cancer 39(6): 648-658

Carrageenan (Cg) was tested for its effects on the growth of, and immunity to, 2 methylcholanthrene-induced syngeneic murine fibrosarcomas (H1 and H2). The tumors did not share major tumor-specific transplantation antigens. H2 appeared more immunogenic than H1. In contrast to H1, immunity induced by H2 was not affected by Cg, nor was its growth in Cg-treated normal mice augmented. Postoperative i.p. injections of Cg abolished the weak anti-H1 immunity produced by H1 tumor excision. The subsequent growth of the H1 tumor challenge in the Cg-treated immune mice was significantly greater than the augmented growth in Cg-treated normal mice. The prior administration of the macrophage-stabilizing agent polyvinylpyrrolidone (PVP) to immune mice significantly reduced the augmenting effect of Cg. The growth-promoting effect of Cg on a secondary H1 tumor challenge in mice immunized by tumor excision was abolished by 106 MCT-H1 cells injected s.c. before Cg. In contrast to the immunity induced by tumor excision, Cg did not abolish the immunity induced by the injection of MCT-H1 cells. Passive administration of H1 tumor-bearer serum (TBS) did not enhance the growth of H1 cells in normal mice, nor did TBS abrogate the specific cell-mediated immunity (CMI) induced in vivo by MCT-H1 cells. TBS administered to Cg-treated, MCT-H1 immune mice abolished tumor immunity. TBS apparently does not inhibit CMI in vivo provided that macrophages remain functional, but may do so when macrophages are rendered defective by anti-macrophage agents or by products of neoplastic cells. Increasing the levels of specific effector cells can over-ride the inhibiting effects of TBS, even when defective macrophages are present.

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Other references

Snieszko, S.F., 1970: A symposium on diseases of fishes and shellfishes. The following papers are included in the Symposium proceedings: Prevention and control of fish diseases in hatcheries, by R. L. Herman (pp. 3-15); Oral immunization of salmonids, by G. W. Klontz & D. P. Anderson (16-29); Role of stress in disease...

Taylor, I., 1993: Changing clinical teaching of British medical students. Lancet 341(8855): 1284-1285

Bolkhovitinova S.S.; Svereva L.A., 1982: Ante natal prophylaxis of fetal hypotrophy. A complex of various prophylactic measures was used in 1770 pregnant women of high risk to prevent prenatal hypotrophy. This complex had a positive effect on the general condition of the patients. It decreased the incidence of acute infections and...

Chapman, R.A.; James, L.G., 1970: The amount of mercury in food products is completely harmless. Les Cahiers du Nursing 43(7): 206-207

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Ott, M., 1966: The Mg content of some Dutch foodstuffs. Mg was estimated with titanium yellow in dry matter of the washed edible portion of vegetables and tubers, when raw or after cooking in boiling or cold water, draining and cooling, also in dry matter of raw legumes and fruits, bread and cereal pro...

Hintz, W., 2007: Development of Chondrostereum purpureum as a mycoherbicide for deciduous brush control. The fungus Chondrostereum purpureum was isolated from a canker on a diseased apple tree in British Columbia. Extensive laboratory and field trials demonstrated that C. purpureum effectively prevents sprouting of cut stumps of deciduous, but not co...

Nosler, D., 1995: Minor and major constituents in goat milk with regard to somatic cell count. For 100 days, milk from udder halves was sampled twice daily and blood once weekly from 2 German Improved White and 4 German Improved Fawn goats in order to determine variables of glycolysis, citrate metabolism and lipolysis. Milk fat, milk protei...

Stenger, J., 2008: Welfare writes. A new employment benefit. Mental Health Today: 21-21

Choi, H.J.; Lee, C.C.; Lim, T.H.; Kang, B.S.; Singer, A.J.; Henry, M.C., 2010: Effectiveness of mouth-to-mouth ventilation after video self-instruction training in laypersons. Mouth-to-mouth ventilation is a skill taught in cardiopulmonary resuscitation (CPR) training for laypersons. However, its effectiveness is questioned. Our aim was to determine the effectiveness of mouth-to-mouth ventilation training using a self-i...