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Effects of diltiazem i.v. on exercise induced myocardial ischemia a study of hemodynamics and reproducibility of hemodynamic findings


, : Effects of diltiazem i.v. on exercise induced myocardial ischemia a study of hemodynamics and reproducibility of hemodynamic findings. Zeitschrift fuer Kardiologie 77(1): 36-43

To obtain data about (a) the reproducibility of repeated standardized exercise tests, under blank and placebo conditions and (b) the improvement of ischaemic symptoms and of haemodynamics after intravenous application of dilitiazem (0.3 mg/kg body weight), 20 patients with angina pectoris and angiographically proven coronary heart disease were analysed in a randomized double-blind study. Results: a) A control exercise test 1 h after the first blank test showed no significant changes of the following parameters neither at rest nor during exercise: heart rate, systolic and diastolic blood pressure, double product, pulmonary capillary wedge pressure, cardiac output, peripheral vascular resistance, stroke volume, ST-segment depression, symptoms of angina pectoris, and maximal work tolerance (steady state, supine position). b) After intravenous application of diltiazem, at rest, both systolic blood pressure (-13 mm Hg, p < 0.03); diastolic blood pressure (-10 mm Hg, p < 0.01) and peripheral vascular resistance (-189 dyn .times. s .times. cm-5, p < 0.02) decreased. During exercise testing, diastolic blood pressure (-9 mm Hg, p < p < 0.02), pulmonary capillary wedge pressure (-13 mm Hg, p < 0.01) and peripheral vascular resistance (-152 dyn .times. s .times. cm-5, p < 0.02) were reduced, and angina pectoris was less severe (p < 0.01): in comparison to placebo the onset of anginal symptoms occurred later (24 vs 49 W, p < 0.01). Maximal exercise tolerance and maximal cardiac output were improved, and ST-segment depression was less pronounced. The study shows that haemodynamic data and ischaemic parameters are well reproducible in repeated exercise tests. Intravenous application of diltiazem leads to afterload reduction and significantly improves ischaemic parameters.

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Other references

Neeraj Pant, Pratibha Fuloria, B.C.Tewari, 2012: A new well behaved exact solution in general relativity for perfect fluid. We present a new spherically symmetric solution of the general relativistic field equations in isotropic coordinates. The solution is having positive finite central pressure and positive finite central density. The ratio of pressure and density is...

Villard, P.H.; Sampol, E.; Elkaim, J.L.; Puyoou, F.; Casanova, D.; Sérée, E.; Durand, A.; Lacarelle, B., 2002: Increase of CYP1B1 transcription in human keratinocytes and HaCaT cells after UV-B exposure. Nonmelanoma skin cancers represent the most common malignant neoplasms in humans. UV-B play a major role in the etiology of these tumors, but exposure to environmental procarcinogens is also involved. CYP catalyzes numerous chemical carcinogen bio...

Kiecolt-Glaser, J.K.; Wilson, S.J., 2017: Lovesick: How Couples' Relationships Influence Health. This review highlights recent advances in research addressing intimate partner relationships and health. Consideration of the strong mutual influences that the members of a couple have on each other's mental and physical health trajectories p...

Ferrari Parabita, G.; Rossi, A.; Vinci, R., 1985: Use of 6-methylprednisolone in maxillofacial surgery. Minerva Stomatologica 34(2): 313-315

White, R.; Wild, J., 2016: "Why" or "How": The Effect of Concrete Versus Abstract Processing on Intrusive Memories Following Analogue Trauma. Emergency service workers, military personnel, and journalists working in conflict zones are regularly exposed to trauma as part of their jobs and suffer higher rates of posttraumatic stress compared with the general population. These individuals...

Titenko-Holland, N.V.; Kowalska, A., 1992: Alpha-1-antitrypsin (PI) subtypes in Russians and Poles. alpha-1-antitrypsin (PI) subtypes were studied in Poles and Russians. The frequencies of the PI alleles were similar in the two populations, with the exception of the Z allele, whose frequency was significantly lower in Poles. The M3 allele freque...

Jones R.L., 1986: Structural aspects of the prostaglandin endoperoxides thromboxanes and prostacyclins. Klein, R A And B Schmitz (Ed ) Topics in Lipid Research: From Structural Elucidation to Biological Function; 3rd International Conference on Lipid Chemistry, Cambridge, England, Uk, April 8-11, Xii+336p Royal Society Of Chemistry: London, England, Uk Illus 65-76

D.Maggio, G., 1952: Pharmacological studies on thiazoles. IX. Effect of associated pyrimidine and thiazole on course of avian beriberi. Bollettino Della Societa Italiana di Biologia Sperimentale 28(12): 1906-1908

Hunter W.E.; Cole J.E., 1972: Spawning site color preference in the fish etroplus maculatus pisces cichlidae. Proceedings of the Pennsylvania Academy of Science 46: 16-17

Schurink, C.A.M.; Visscher, S.; Lucas, P.J.F.; van Leeuwen, H.J.; Buskens, E.; Hoff, R.G.; Hoepelman, A.I.M.; Bonten, M.J.M., 2007: A Bayesian decision-support system for diagnosing ventilator-associated pneumonia. To determine the diagnostic performance of a Bayesian Decision-Support System (BDSS) for ventilator-associated pneumonia (VAP). A previously developed BDSS, automatically obtaining patient data from patient information systems, provides likelihood...