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Effects of exercise training and exhaustion on calcium 45 uptake by rat skeletal muscle mitochondria and sarcoplasmic reticulum

, : Effects of exercise training and exhaustion on calcium 45 uptake by rat skeletal muscle mitochondria and sarcoplasmic reticulum. Research Communications in Chemical Pathology and Pharmacology 14(4): 767-770

Mitochondrial and sarcoplasmic reticular 45Ca2+ uptake and Ca2+-ATPase activity were determined in skeletal muscle from exercise trained and non-trained rats at rest or following short-term exhaustive exercise. In trained rats exercised to exhaustion, mitochondrial 45Ca2+ uptake was significantly depressed when compared to non-trained rats at rest. Ca2+-ATPase activity of sarcoplasmic reticulum from trained rats exercised to exhaustion was significantly increased as compared to trained rats at rest. The disruptive influence of Ca2+ accumulation in mitochondria isolated following exhaustive exercise may be diminished as a result of training.


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