geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of nifedipine slow release tablet on cerebral circulation


, : Effects of nifedipine slow release tablet on cerebral circulation. Current Therapeutic Research 44(3): 485-492

One tablet of nifedipine slow-release preparation (20 mg) was administered twice daily for eight weeks to ten patients (.gtoreq. 65 years old) with hypertension complicated by ischemic cerebrovascular disease (cerebral arteriosclerosis and sequelae of cerebral apoplexy). Change in cerebral circulation, blood pressure, and pulse rate as well as side effects were evaluated before and after drug administration. Cerebral blood flow was unchanged in six patients (60%), and increased in four patients (40%), but decreased in none. Cerebrovascular resistance decreased in all patients. No significance difference was observed in blood flow nor in vascular resistance between the internal carotoid and the vertebral arteries. Both systolic and diastolic pressure significantly decreased after drug administration, but no significant change was observed in pulse rats. No side effects except for mild symtpoms of dizziness and general malaise and hot flashes in two patients were observed. These results showed the usefulness of nifedipine slow-release tablet in treating hypertension complicated by ischemic cerebrovascular disease in the elderly.

US$29.90


Other references

Sharma, N., 2017: Entrustment Versus Competency-Continued Confusion. Journal of Graduate Medical Education 9(3): 400-400

Kawatsu, M.; Yamashita, T.; Ishizuka, M.; Takeuchi, T., 1995: Improvement of efficacy of antitumor agents by conagenin. The antitumor efficacy of antitumor agents at sublethal doses was investigated in combination with conagenin (CNG) against murine leukemias. Mice were inoculated with 1 x 10(3) L1210 cells i.v. and given 300 mg/kg of cyclophosphamide (CY) i.p. on...

Khan, O.F.; Sefton, M.V., 2011: Endothelialized biomaterials for tissue engineering applications in vivo. Rebuilding tissues involves the creation of a vasculature to supply nutrients and this in turn means that the endothelial cells (ECs) of the resulting endothelium must be a quiescent non-thrombogenic blood contacting surface. Such ECs are deployed...

Kawada, H.; Ando, K.; Tsuji, T.; Shimakura, Y.; Nakamura, Y.; Chargui, J.; Hagihara, M.; Itagaki, H.; Shimizu, T.; Inokuchi, S.; Kato, S.; Hotta, T., 1999: Rapid ex vivo expansion of human umbilical cord hematopoietic progenitors using a novel culture system. Cell numbers limit the widespread clinical use of cord blood (CB) for gene therapy and marrow replacement in adults; a simple and effective method for ex vivo expansion of CB primitive progenitor cells (PPC) is required. Recently, the combination...

Sander, M.; Hanada, A.; Green, E.R., 2000: Differential regulation of renal, mesenteric and muscle blood flows during nitric oxide inhibition in humans. Acta Physiologica Scandinavica 170(4): A26-A27, December

Simon R.I., 1987: The psychiatrist as a fiduciary avoiding the double agent role. Psychiatric Annals 17(9): 622-626

Pugazhenthiran, N.; Sen Gupta, S.; Prabhath, A.; Manikandan, M.; Swathy, J.Ravindran.; Raman, V.Kalyan.; Pradeep, T., 2016: Cellulose Derived Graphenic Fibers for Capacitive Desalination of Brackish Water. We describe a simple and inexpensive cellulose-derived and layer-by-layer stacked carbon fiber network electrode for capacitive deionization (CDI) of brackish water. The microstructure and chemical composition were characterized using spectroscopi...

Dukhanina, N.N., 1960: Russian literature on problems of medical parasitology and parasitic diseases in 1959. Meditsinskaia Parazitologiia i Parazitarnye Bolezni 29: 242-8 Contd

Rodríguez-Leal, G.A.; Moran-Villota, S.; Arista-Nasr, J.; Uribe-Esquivel, M., 1997: Case report of multiple myeloma and hypothyroidism in primary biliary cirrhosis. A 71-year-old female with primary biliary cirrhosis, multiple myeloma and hypothyroidism is reported. The liver biopsy showed stage II-III histologic damage according to Scheuer's classification and the multiple myeloma was IgG-lambda type, s...

Mikhaylov G.K.; Yakovlev Y.A.; Yakushev V.F., 1981: Trace element gaseous composition of ground water; an indicator of structural-tectonic conditions. Pages 44-47 1981