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Effects of solvents on the production of epoxides by nocardia corallina b 276


, : Effects of solvents on the production of epoxides by nocardia corallina b 276. Applied Microbiology & Biotechnology 23(3-4): 218-223

Glucose-grown cells of Nocardia corallina B-276 produced epoxides from C2 to C18 1-alkenes and styrene. Production of epoxides from C6-C10 1-alkenes and styrene was enhanced by the addition of n-hexadecane as a solvent to the reaction system, while addition of n-hexadecane decreased the rate of epoxidation of longer chain length 1-alkenes. n-Hexadecane was found to reduce substrate inhibition by styrene and product inhibition by styreneoxide and 1,2-epoxyalkanes. n-Alkanes, 1-alkenes, alkylbenzenes, halogenated alkanes and a diester of a dibasic acid could be used as solvents.

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