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Effects of the aromatase inhibitor 1 4 6 androstatriene 3 17 dione and the anti estrogen tamoxifen on rat testicular function


, : Effects of the aromatase inhibitor 1 4 6 androstatriene 3 17 dione and the anti estrogen tamoxifen on rat testicular function. Journal of Steroid Biochemistry 14(9): 823-828

The time course (12-72 h) of the effects of 1,4,6-androstatriene-3,17-dione (ATD) and tamoxifen on plasma levels and testicular concentrations of testosterone (T), 17.alpha.-hydroxyprogesterone (17-OHP) and progesterone (Pro) was studied in adult rats, and compared with the well known inhibitory action of estradiol benzoate (E2B). Under basal conditions treatment with ATD (10 mg every 12 h) or tamoxifen (100 .mu.g as a single dose) resulted in a rise in plasma testosterone (T) and LH [lutropin] levels, in contrast to E2B therapy (100 .mu.g as a single dose) which caused a significant decrease in testicular steroidogenesis and in LH secretion. The acute testicular response (2 h) to 500 IU hCG [human chorionic gonadotropin] was significantly diminished in animals treated with either ATD or tamoxifen, although less so than with E2B treatment. Plasma levels and testicular contents of T and 17-OHP correlated well, but plasma Pro correlated poorly with testicular Pro, especially under E2B treatment. Subsequent work on adrenalectomized rats demonstrated that almost all the plasma Pro measured in intact rats was adrenal, rather than testicular, in origin. The increase in endogenous LH caused by ATD and tamoxifen apparently enhanced steroidogenesis under basal conditions, but induced a partial steroidogenic refractoriness of the testis to hCG.

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PMID: 7300351


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