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Endorphins and placebo fear reduction

, : Endorphins and placebo fear reduction. Psychological Reports 51(3 Pt 2): 1175-1181

Whether endorphins play a role in placebo fear reduction in addition to their apparent mediation of placebo analgesia was examined. Female undergraduate students (22) were i.v. administered saline or the endorphin antagonist, naloxone, under double-blind conditions prior to exposure to a nonspecific analog treatment for snake fear. The 2 groups of subjects performed comparably and significantly better than no-treatment controls on posttest measures of self-efficacy, self-rated fear and approach toward a live, harmless snake. A mechanism other than endorphin release apparently underlies fear reduction in psychological placebo treatments.


PMID: 6300951

DOI: 10.2466/pr0.1982.51.3f.1175

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