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Epinephrine independent production of hyper uricemia by hypothalamic stimulation in the conscious rat


, : Epinephrine independent production of hyper uricemia by hypothalamic stimulation in the conscious rat. Life Sciences 28(10): 1183-1188

The electrical stimulation of the ventromedial hypothalamus with 0.6 mA current produced an acute hyperuricemia associated with a rise in plasma allantoin in the conscious rat. Adrenal demedullation did not depress the hyperuricemic response. Even after the demedullation, neither propranolol nor phentolamine had any significant effects. These results indicate that endogeneous catecholamines are not involved in the production of the hyperuricemia; this is in sharp contrast with a previous result demonstrating the development of hyperuricemia via adrenal epinephrine by stimulating the ventromedial nucleus with 0.2 mA current. Ventromedial hypothalamic stimulation is capable of producing 2 different types of hyperuricemia, i.e., adrenal-epinephrine-dependent and epinephrine-independent, by varying the intensity of the stimulation current.

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