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Evidence of a role for gamma amino butyric acid in benzodiazepine effects on food preference in rats


, : Evidence of a role for gamma amino butyric acid in benzodiazepine effects on food preference in rats. Psychopharmacology 75(3): 305-310

Chronic treatment with the GABA-transaminase inhibitor ethanolamine-O-sulfate (EOS), which elevates brain GABA levels by .apprx. 200%, selectivity enhances novel food consumption in rats treated with chlordiazepoxide (CDP) and given a food preference test. To replicate and extend these findings, the effects of 2 doses of CDP with and without EOS pretreatment were compared with those of EOS or saline alone. EOS alone had no significant effects except to decrease eating rate but, in combination with 2.5 mg/kg CDP, it antagonized the increase in weight of familiar food eaten found with CDP alone and marginally increased weight eaten and duration of novel food-eating episodes. EOS magnified the effects of 5.0 mg/kg CDP to increase markedly the weight eaten and duration of episodes for novel chocolate drops. As no additive effects of EOS and CDP on rate of eating were found, the results are consistent with a facilitation of novel food consumption by an anxiolytic action of the 2 drugs, rather than by a rate-retarding action which might bias animals toward novel food. That EOS alone did not mimic the effects of CDP suggests that the role of GABA in the anxiolytic action of CDP may be indirect.

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